| Literature DB >> 31914447 |
Francesca Cirillo1, Cecilia Catellani1, Pietro Lazzeroni1, Chiara Sartori1, Maria Elisabeth Street2.
Abstract
Body growth and development are regulated among others by genetic and epigenetic factors. MicroRNAs (miRNAs) are epigenetic regulators of gene expression that act at the post-transcriptional level, thereby exerting a strong influence on regulatory gene networks. Increasing studies suggest the importance of miRNAs in the regulation of the growth plate and growth hormone (GH)-insulin-like growth factor (IGF) axis during the life course in a broad spectrum of animal species, contributing to longitudinal growth. This review summarizes the role of miRNAs in regulating growth in different in vitro and in vivo models acting on GH, GH receptor (GHR), IGFs, and IGF1R genes besides current knowledge in humans, and highlights that this regulatory system is of importance for growth.Entities:
Keywords: Body size; Development; Growth; Growth hormone; Insulin-like growth factor-I; MicroRNA
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Year: 2020 PMID： 31914447 DOI： 10.1159/000504669
Source DB: PubMed Journal: Horm Res Paediatr ISSN： 1663-2818 Impact factor: 2.852