Ana Sofia Coelho1,2,3,4,5, Inês Flores Amaro1, Francisco Caramelo2,3,4,5,6, Anabela Paula1,2,3,4,5, Carlos Miguel Marto1,2,3,4,5,7, Manuel Marques Ferreira2,3,4,5,8, Maria Filomena Botelho2,3,4,5, Eunice Virgínia Carrilho1,2,3,4,5. 1. Faculty of Medicine, Institute of Integrated Clinical Practice, University of Coimbra, Coimbra, Portugal. 2. Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, Portugal. 3. Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. 4. Faculty of Medicine, CIMAGO-Center of Investigation on Environment, Genetics and Oncobiology, University of Coimbra, Coimbra, Portugal. 5. CNC.IBILI, University of Coimbra, Coimbra, Portugal. 6. Faculty of Medicine, Laboratory of Biostatistics and Medical Informatics, University of Coimbra, Coimbra, Portugal. 7. Faculty of Medicine, Experimental Pathology Institute, University of Coimbra, Coimbra, Portugal. 8. Faculty of Medicine, Institute of Endodontics, University of Coimbra, Coimbra, Portugal.
Abstract
OBJECTIVE: To analyze articles aimed at evaluating the association between diabetes, metabolic control, diabetes duration, and dental caries. OVERVIEW: A systematic search in PubMed, Cochrane Library, Embase, and Web of Science was conducted to retrieve papers in English, Portuguese, and Spanish, up to April 2019. The research strategy was constructed considering the "PECO" strategy. Only quantitative observational studies were analyzed. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. The meta-analyses were performed based on random-effects models using the statistical platform R. A total of 69 articles was included in the systematic review and 40 in the meta-analysis. Type 1 diabetics have a significantly higher DMFT compared to controls. No significant differences were found between type 2 diabetics and controls and between well-controlled and poorly controlled diabetics. Concerning diabetes duration, all authors failed to find differences between groups. CONCLUSION: Although there is still a need for longitudinal studies, the meta-analysis proved that type 1 diabetics have a high dental caries risk. CLINICAL SIGNIFICANCE: It is necessary to be aware of all risk factors for dental caries that may be associated with these patients, making it possible to include them into an individualized prevention program.
OBJECTIVE: To analyze articles aimed at evaluating the association between diabetes, metabolic control, diabetes duration, and dental caries. OVERVIEW: A systematic search in PubMed, Cochrane Library, Embase, and Web of Science was conducted to retrieve papers in English, Portuguese, and Spanish, up to April 2019. The research strategy was constructed considering the "PECO" strategy. Only quantitative observational studies were analyzed. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. The meta-analyses were performed based on random-effects models using the statistical platform R. A total of 69 articles was included in the systematic review and 40 in the meta-analysis. Type 1 diabetics have a significantly higher DMFT compared to controls. No significant differences were found between type 2 diabetics and controls and between well-controlled and poorly controlled diabetics. Concerning diabetes duration, all authors failed to find differences between groups. CONCLUSION: Although there is still a need for longitudinal studies, the meta-analysis proved that type 1 diabetics have a high dental caries risk. CLINICAL SIGNIFICANCE: It is necessary to be aware of all risk factors for dental caries that may be associated with these patients, making it possible to include them into an individualized prevention program.
Authors: Thais de Cássia Negrini; Iracilda Zeppone Carlos; Cristiane Duque; Karina Sampaio Caiaffa; Rodrigo Alex Arthur Journal: Front Oral Health Date: 2021-09-09