Julia Gonçalves Koehne de Castro1, Bruno Fontenele Carvalho1, Nilce Santos de Melo1, Paulo Tadeu de Souza Figueiredo1, Carla Ruffeil Moreira-Mesquita1, Karla de Faria Vasconcelos2, Reinhilde Jacobs2,3, André Ferreira Leite4,5. 1. Department of Dentistry, Faculty of Health Sciences, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Zip Code 70910-900, Brazil. 2. Department Imaging and Pathology, Biomedical Sciences, Omfsimpath Research Group, KULeuven and Dentomaxillofacial Imaging Department, University Hospitals Leuven, Leuven, Belgium. 3. Department Dental Medicine, Karolinska Institutet, Huddinge, Sweden. 4. Department of Dentistry, Faculty of Health Sciences, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Zip Code 70910-900, Brazil. andreleite@unb.br. 5. Department Imaging and Pathology, Biomedical Sciences, Omfsimpath Research Group, KULeuven and Dentomaxillofacial Imaging Department, University Hospitals Leuven, Leuven, Belgium. andreleite@unb.br.
Abstract
OBJECTIVE: To verify whether mandibular cortical analyses accurately distinguish postmenopausal women with normal bone mineral density (BMD) from women with osteoporosis by means of a cone-beam computed tomography (CBCT)-driven composite osteoporosis index (three-dimensional mandibular osteoporosis index-3D MOI). MATERIAL AND METHODS: The comparison was performed between 52 women with normal BMD and 51 women with osteoporosis according to dual-energy X-ray absorptiometry (DXA) examination of the lumbar spine and hip. Mandibular cortical width (MCW) and cortical quality were evaluated on cross-sectional and panoramic reconstructed images. ANOVA, ROC curves and accuracy measurements were used for statistical analyses, as well as a predictive model combining the quantitative and qualitative analyses and age. RESULTS: All CBCT-driven measurements presented good to moderate intra- and interobserver agreements. MCW values were significantly lower in women with osteoporosis. Postmenopausal women with osteoporosis were 8 times more likely to have the cortex classified as C3, and 2.4 times more likely to have MCW thinner than 2.75 mm. The area under the ROC curve was 0.8 for the predictive model. CONCLUSIONS: The newly developed 3D MOI enables distinguishing women with osteoporosis from those with normal BMD with good sensitivity and specificity. CLINICAL RELEVANCE: Whenever a CBCT scan is performed for specific clinical indications, a 3D MOI may be performed to qualitatively and quantitatively assess the condition of the mandibular cortex. This may be surely helpful to assess the osteoporosis status in the ageing population and more specifically in peri- or postmenopausal women.
OBJECTIVE: To verify whether mandibular cortical analyses accurately distinguish postmenopausal women with normal bone mineral density (BMD) from women with osteoporosis by means of a cone-beam computed tomography (CBCT)-driven composite osteoporosis index (three-dimensional mandibular osteoporosis index-3D MOI). MATERIAL AND METHODS: The comparison was performed between 52 women with normal BMD and 51 women with osteoporosis according to dual-energy X-ray absorptiometry (DXA) examination of the lumbar spine and hip. Mandibular cortical width (MCW) and cortical quality were evaluated on cross-sectional and panoramic reconstructed images. ANOVA, ROC curves and accuracy measurements were used for statistical analyses, as well as a predictive model combining the quantitative and qualitative analyses and age. RESULTS: All CBCT-driven measurements presented good to moderate intra- and interobserver agreements. MCW values were significantly lower in women with osteoporosis. Postmenopausal women with osteoporosis were 8 times more likely to have the cortex classified as C3, and 2.4 times more likely to have MCW thinner than 2.75 mm. The area under the ROC curve was 0.8 for the predictive model. CONCLUSIONS: The newly developed 3D MOI enables distinguishing women with osteoporosis from those with normal BMD with good sensitivity and specificity. CLINICAL RELEVANCE: Whenever a CBCT scan is performed for specific clinical indications, a 3D MOI may be performed to qualitatively and quantitatively assess the condition of the mandibular cortex. This may be surely helpful to assess the osteoporosis status in the ageing population and more specifically in peri- or postmenopausal women.
Entities:
Keywords:
Bone density; Cone-beam computed tomography; Osteoporosis; Sensitivity and specificity
Authors: Bruno Fontenele Carvalho; Julia Gonçalves Koehne de Castro; Nilce Santos de Melo; Paulo Tadeu de Souza Figueiredo; Carla Ruffeil Moreira-Mesquita; Ana Patrícia de Paula; Rafael Sindeaux; André Ferreira Leite Journal: Imaging Sci Dent Date: 2022-01-13