Literature DB >> 319122

A double-blind comparison of meptazinol with placebo in postoperative pain.

A Hedges, J Rose, M Leighton, P Turner.   

Abstract

In a double-blind clinical trial, meptazinol (400-mg capsules) was shown to be significantly better than placebo in relieving postoperative pain in patients who had under gone total abdominal hysterectomy operations. Analgesic activity was assessed by patients rating their pain before and 1 hour after the administration of each treatment, by sequential analysis of patient and investigator preference for treatment, and by calculating the time interval between doses of the two treatments.

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Year:  1977        PMID: 319122     DOI: 10.1002/j.1552-4604.1977.tb04598.x

Source DB:  PubMed          Journal:  J Clin Pharmacol        ISSN: 0091-2700            Impact factor:   3.126


  4 in total

1.  Post-surgical pain relief with zero-order intravenous infusions of meptazinol and morphine: a double-blind placebo-controlled evaluation of their effects on ventilation.

Authors:  C Verborgh; F Camu
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953

2.  Assessment of analgesic drugs in soft tissue injuries presenting to an accident and emergency department--a comparison of antrafenine, paracetamol and placebo.

Authors:  C de Gara; M Taylor; A Hedges
Journal:  Postgrad Med J       Date:  1982-08       Impact factor: 2.401

3.  Effects of graded oral doses of meptazinol and pentazocine in comparison with placebo on experimentally induced pain in healthy humans.

Authors:  G Stacher; H Steinringer; S Winklehner; G Mittelbach; C Schneider
Journal:  Br J Clin Pharmacol       Date:  1983-08       Impact factor: 4.335

Review 4.  Meptazinol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy.

Authors:  B Holmes; A Ward
Journal:  Drugs       Date:  1985-10       Impact factor: 9.546

  4 in total

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