Literature DB >> 31912071

Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function.

Katarzyna Kluska1, Manuel D Peris-Díaz1, Dawid Płonka2, Alexander Moysa2, Michał Dadlez2, Aurélien Deniaud3, Wojciech Bal2, Artur Krężel1.   

Abstract

Silver (Ag(i)) binding to consensus zinc fingers (ZFs) causes Zn(ii) release inducing a gradual disruption of the hydrophobic core, followed by an overall conformational change and formation of highly stable AgnSn clusters. A compact eight-membered Ag4S4 structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Ag(i)-induced conformational changes of ZFs can, as a consequence, affect transcriptional regulation and other cellular processes.

Entities:  

Year:  2020        PMID： 31912071     DOI： 10.1039/c9cc09418k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Size-Dependent Bioactivity of Silver Nanoparticles: Antibacterial Properties, Influence on Copper Status in Mice, and Whole-Body Turnover.

Authors:  Ekaterina A Skomorokhova; Tatiana P Sankova; Iurii A Orlov; Andrew N Savelev; Daria N Magazenkova; Mikhail G Pliss; Alexey N Skvortsov; Ilya M Sosnin; Demid A Kirilenko; Ivan V Grishchuk; Elena I Sakhenberg; Elena V Polishchuk; Pavel N Brunkov; Alexey E Romanov; Ludmila V Puchkova; Ekaterina Yu Ilyechova
Journal:  Nanotechnol Sci Appl       Date:  2020-12-31

2.  Cirrhotic Liver of Liver Transplant Recipients Accumulate Silver and Co-Accumulate Copper.

Authors:  Jarosław Poznański; Dariusz Sołdacki; Bożena Czarkowska-Pączek; Arkadiusz Bonna; Oskar Kornasiewicz; Marek Krawczyk; Wojciech Bal; Leszek Pączek
Journal:  Int J Mol Sci       Date:  2021-02-11       Impact factor: 5.923

3.  Phytochelatins as a Dynamic System for Cd(II) Buffering from the Micro- to Femtomolar Range.

Authors:  Joanna Wątły; Marek Łuczkowski; Michał Padjasek; Artur Krężel
Journal:  Inorg Chem       Date:  2021-03-18       Impact factor: 5.165

4.  SARS-CoV-2 Virion Stabilization by Zn Binding.

Authors:  Silvia Morante; Giovanni La Penna; Giancarlo Rossi; Francesco Stellato
Journal:  Front Mol Biosci       Date:  2020-09-17

5.  Structures of Silver Fingers and a Pathway to Their Genotoxicity.

Authors:  Katarzyna Kluska; Giulia Veronesi; Aurélien Deniaud; Bálint Hajdu; Béla Gyurcsik; Wojciech Bal; Artur Krężel
Journal:  Angew Chem Int Ed Engl       Date:  2022-02-03       Impact factor: 16.823
  5 in total

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