Sadaf Alipour1,2, Ramesh Omranipour1,3, Frederic Amant4,5, Bita Eslami1. 1. Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Surgery, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. 3. Department of Surgical Oncology, Tehran University of Medical Sciences, Tehran, Iran. 4. Department of Oncology, KU Leuven, Leuven, Belgium. 5. Center for Gynecologic Oncology Amsterdam, Netherlands Cancer Institute and Amsterdam University Medical Centers, Amsterdam, Netherlands.
Abstract
OBJECTIVE: Approach to precancerous and high-risk breast lesions occurring in pregnancy has received little attention in the literature. We carried out a study to investigate the practice of surgeons in the management of these cases. MATERIALS AND METHODS: A short survey was sent to surgeons, including a multiple-choice questionnaire about their practice for atypical hyperplasia or lobular carcinoma in situ presenting in each trimester of pregnancy or at time of breastfeeding. Answer options included observation, immediate vacuum biopsy, immediate surgery, surgery in next trimester, surgery after delivery, and surgery after end of breastfeeding; based on the time of presentation. RESULTS: Out of the 671 practitioners invited, 97(14.5 %) responded to the survey. Participants were from 23 countries. Answers showed that management of gestational Atypical Ductal Hyperplasia (ADH) and Lobular Neoplasia (LN) was readily postponed by surgeons in favor of fetus safety while being cautious about risks of conservative management alone. CONCLUSION: Various methods of treatment are selected by surgeons for managing high-risk breast lesions during pregnancy. In the absence of relevant literature, decision making in a multidisciplinary team would be the best approach in these cases.
OBJECTIVE: Approach to precancerous and high-risk breast lesions occurring in pregnancy has received little attention in the literature. We carried out a study to investigate the practice of surgeons in the management of these cases. MATERIALS AND METHODS: A short survey was sent to surgeons, including a multiple-choice questionnaire about their practice for atypical hyperplasia or lobular carcinoma in situ presenting in each trimester of pregnancy or at time of breastfeeding. Answer options included observation, immediate vacuum biopsy, immediate surgery, surgery in next trimester, surgery after delivery, and surgery after end of breastfeeding; based on the time of presentation. RESULTS: Out of the 671 practitioners invited, 97(14.5 %) responded to the survey. Participants were from 23 countries. Answers showed that management of gestational Atypical Ductal Hyperplasia (ADH) and Lobular Neoplasia (LN) was readily postponed by surgeons in favor of fetus safety while being cautious about risks of conservative management alone. CONCLUSION: Various methods of treatment are selected by surgeons for managing high-risk breast lesions during pregnancy. In the absence of relevant literature, decision making in a multidisciplinary team would be the best approach in these cases.
Authors: Alvaro Peña; Sejal S Shah; Robert T Fazzio; Tanya L Hoskin; Rushin D Brahmbhatt; Tina J Hieken; James W Jakub; Judy C Boughey; Daniel W Visscher; Amy C Degnim Journal: Breast Cancer Res Treat Date: 2017-05-04 Impact factor: 4.872
Authors: Christoph J Rageth; Elizabeth Am O'Flynn; Christopher Comstock; Claudia Kurtz; Rahel Kubik; Helmut Madjar; Domenico Lepori; Gert Kampmann; Alexander Mundinger; Astrid Baege; Thomas Decker; Stefanie Hosch; Christoph Tausch; Jean-François Delaloye; Elisabeth Morris; Zsuzsanna Varga Journal: Breast Cancer Res Treat Date: 2016-08-13 Impact factor: 4.872