Literature DB >> 31911338

Advances in visualization of copper in mammalian systems using X-ray fluorescence microscopy.

Scot C Leary1, Martina Ralle2.   

Abstract

Synchrotron-based X-ray fluorescence microscopy (XFM) has become an important imaging technique to investigate elemental concentrations and distributions in biological specimens. Advances in technology now permit imaging at resolutions rivaling that of electron microscopy, and researchers can now visualize elemental concentrations in subcellular organelles when using appropriate correlative methods. XFM is an especially valuable tool to determine the distribution of endogenous trace metals that are involved in neurodegenerative diseases. Here, we discuss the latest research on the unusual copper (Cu) storage vesicles that were originally identified in mouse brains and the involvement of Cu in Alzheimer's disease. Finally, we provide an outlook of how future improvements to XFM will drive current trace element research forward.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Copper dyshomeostasis in Alzheimer's disease; Copper storage vesicles; X-ray fluorescence microscopy

Mesh：

Substances：

Year:  2020        PMID： 31911338      PMCID： PMC7237281          DOI： 10.1016/j.cbpa.2019.12.002

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  27 in total

1.  Wilson disease at a single cell level: intracellular copper trafficking activates compartment-specific responses in hepatocytes.

Authors:  Martina Ralle; Dominik Huster; Stefan Vogt; Wiebke Schirrmeister; Jason L Burkhead; Tony R Capps; Lawrence Gray; Barry Lai; Edward Maryon; Svetlana Lutsenko
Journal:  J Biol Chem       Date:  2010-07-20       Impact factor: 5.157

2.  Elevated copper in the amyloid plaques and iron in the cortex are observed in mouse models of Alzheimer's disease that exhibit neurodegeneration.

Authors:  Megan W Bourassa; Andreana C Leskovjan; Ryan V Tappero; Erik R Farquhar; Carol A Colton; William E Van Nostrand; Lisa M Miller
Journal:  Biomed Spectrosc Imaging       Date:  2013-04-01

3.  Zinc and Copper Effects on Stability of Tubulin and Actin Networks in Dendrites and Spines of Hippocampal Neurons.

Authors:  Laura Perrin; Stéphane Roudeau; Asuncion Carmona; Florelle Domart; Jennifer D Petersen; Sylvain Bohic; Yang Yang; Peter Cloetens; Richard Ortega
Journal:  ACS Chem Neurosci       Date:  2017-04-03       Impact factor: 4.418

4.  X-ray Absorption Spectroscopy Investigations of Copper(II) Coordination in the Human Amyloid β Peptide.

Authors:  Kelly L Summers; Kevin M Schilling; Graham Roseman; Kate A Markham; Natalia V Dolgova; Thomas Kroll; Dimosthenis Sokaras; Glenn L Millhauser; Ingrid J Pickering; Graham N George
Journal:  Inorg Chem       Date:  2019-04-23       Impact factor: 5.165

Review 5.  Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes.

Authors:  Sook-Jeong Lee; Jae-Young Koh
Journal:  Mol Brain       Date:  2010-10-26       Impact factor: 4.041

6.  Aging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zone.

Authors:  Yulia Pushkar; Gregory Robison; Brendan Sullivan; Sherleen X Fu; Meghan Kohne; Wendy Jiang; Sven Rohr; Barry Lai; Matthew A Marcus; Taisiya Zakharova; Wei Zheng
Journal:  Aging Cell       Date:  2013-07-08       Impact factor: 9.304

7.  Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.

Authors:  Helena Öhrvik; Yasuhiro Nose; L Kent Wood; Byung-Eun Kim; Sophie-Charlotte Gleber; Martina Ralle; Dennis J Thiele
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-28       Impact factor: 11.205

8.  Iron, Copper, and Zinc Concentration in Aβ Plaques in the APP/PS1 Mouse Model of Alzheimer's Disease Correlates with Metal Levels in the Surrounding Neuropil.

Authors:  Simon A James; Quentin I Churches; Martin D de Jonge; Ian E Birchall; Victor Streltsov; Gawain McColl; Paul A Adlard; Dominic J Hare
Journal:  ACS Chem Neurosci       Date:  2016-12-22       Impact factor: 4.418

9.  Age-dependent increase of brain copper levels and expressions of copper regulatory proteins in the subventricular zone and choroid plexus.

Authors:  Sherleen Fu; Wendy Jiang; Wei Zheng
Journal:  Front Mol Neurosci       Date:  2015-06-08       Impact factor: 5.639

10.  On the nature of the Cu-rich aggregates in brain astrocytes.

Authors:  Brendan Sullivan; Gregory Robison; Jenna Osborn; Martin Kay; Peter Thompson; Katherine Davis; Taisiya Zakharova; Olga Antipova; Yulia Pushkar
Journal:  Redox Biol       Date:  2016-12-09       Impact factor: 11.799
View more
  3 in total

Review 1.  Dynamic and cell-specific transport networks for intracellular copper ions.

Authors:  Svetlana Lutsenko
Journal:  J Cell Sci       Date:  2021-11-04       Impact factor: 5.285

2.  Single-cell visualization and quantification of trace metals in Chlamydomonas lysosome-related organelles.

Authors:  Stefan Schmollinger; Si Chen; Daniela Strenkert; Colleen Hui; Martina Ralle; Sabeeha S Merchant
Journal:  Proc Natl Acad Sci U S A       Date:  2021-04-20       Impact factor: 11.205

3.  Oral Elesclomol Treatment Alleviates Copper Deficiency in Animal Models.

Authors:  Sai Yuan; Tamara Korolnek; Byung-Eun Kim
Journal:  Front Cell Dev Biol       Date:  2022-04-01
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.