Matteo Nicola Dario Di Minno1, Francesco Forte2, Antonella Tufano2, Agostino Buonauro3, Francesca Wanda Rossi4, Amato De Paulis4, Maurizio Galderisi3. 1. Department of Translational Medical Sciences, Federico II University, Via S. Pansini 5, 80131 Naples, Italy. Electronic address: dario.diminno@hotmail.it. 2. Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. 3. Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy. 4. Department of Translational Medical Sciences, Federico II University, Via S. Pansini 5, 80131 Naples, Italy.
Abstract
BACKGROUND: Systemic lupus erythematosus (SLE), is characterized by a systemic involvement including myocardial dysfunction. Being standard echocardiography not able at fully detecting subclinical alterations, speckle tracking echocardiography (STE) has recently emerged as a quantitative ultrasound technique to accurately estimate myocardial function. METHODS: We conducted a systematic review with meta-analysis of studies reporting STE parameters in patients with SLE. RESULTS: A total of 9 studies were included in the analysis. Left ventricle global longitudinal strain (GLS) was significantly lower in SLE patients than in non-SLE controls (MD: -2.331, 95% CI: -3.083, -1.580, p < 0.001). In addition, we found significant differences between SLE patients and non-SLE controls in left ventricle GLS rate (MD: -0.115, 95% CI: -0.177 to 0.063, p < 0.001), left ventricle circumferential strain(MD: -1.841, 95% CI: -3.160 to 0.521, p = 0.006) and left ventricle radial strain(MD: -11.03, 95% CI: -13.819 to 8.241, p < 0.001). Right ventricle strain was significantly lower in SLE patients than in non-SLE controls (MD: -5.814, 95% CI: -7.347, -4.281, p < 0.001). Meta-regression models showed a lower difference in left ventricle GLS between SLE cases and controls for studies with a higher prevalence of female gender and higher prevalence of hypertension. CONCLUSIONS: SLE patients have lower STE parameters than controls, thus suggesting the presence of an impaired myocardial function involving both left and right ventricle.
BACKGROUND:Systemic lupus erythematosus (SLE), is characterized by a systemic involvement including myocardial dysfunction. Being standard echocardiography not able at fully detecting subclinical alterations, speckle tracking echocardiography (STE) has recently emerged as a quantitative ultrasound technique to accurately estimate myocardial function. METHODS: We conducted a systematic review with meta-analysis of studies reporting STE parameters in patients with SLE. RESULTS: A total of 9 studies were included in the analysis. Left ventricle global longitudinal strain (GLS) was significantly lower in SLE patients than in non-SLE controls (MD: -2.331, 95% CI: -3.083, -1.580, p < 0.001). In addition, we found significant differences between SLE patients and non-SLE controls in left ventricle GLS rate (MD: -0.115, 95% CI: -0.177 to 0.063, p < 0.001), left ventricle circumferential strain(MD: -1.841, 95% CI: -3.160 to 0.521, p = 0.006) and left ventricle radial strain(MD: -11.03, 95% CI: -13.819 to 8.241, p < 0.001). Right ventricle strain was significantly lower in SLE patients than in non-SLE controls (MD: -5.814, 95% CI: -7.347, -4.281, p < 0.001). Meta-regression models showed a lower difference in left ventricle GLS between SLE cases and controls for studies with a higher prevalence of female gender and higher prevalence of hypertension. CONCLUSIONS: SLE patients have lower STE parameters than controls, thus suggesting the presence of an impaired myocardial function involving both left and right ventricle.
Authors: Joyce C Chang; Yan Wang; Rui Xiao; Anysia Fedec; Kevin E Meyers; Craig Tinker; Shobha S Natarajan; Andrea M Knight; Pamela F Weiss; Laura Mercer-Rosa Journal: Echocardiography Date: 2020-10-03 Impact factor: 1.724
Authors: Shereen Ibrahim Farag; Reda Biomy Bastawisy; Mohamed Ahmed Hamouda; Wael Anwer Hassib; Hala Ahmed Wahdan Journal: J Cardiovasc Echogr Date: 2020-11-09