Literature DB >> 3190997

Linearity of metoclopramide kinetics at doses of 5-20 mg.

M R Wright1, J E Axelson, D W Rurak, B McErlane, G H McMorland, R C Ongley, Y K Tam, J D Price.   

Abstract

The disposition of metoclopramide was studied on a four-way crossover basis in six healthy non-smoking volunteers. The linearity of kinetic parameters and absolute bioavailability of metoclopramide were examined. In contrast to previous reports, metoclopramide obeyed linear kinetics over oral doses ranging from 5 to 20 mg. The absolute bioavailability of metoclopramide was 0.76 +/- 0.38 (mean +/- s.d.) from the oral dosage forms examined in this study.

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Year:  1988        PMID： 3190997      PMCID： PMC1386570          DOI： 10.1111/j.1365-2125.1988.tb03407.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  7 in total

1.  Effect of growth in lithium on ouabain binding, Na-K-ATPase and Na and K transport in hela cells.

Authors:  L J Boardman; S P Hume; J F Lamb; J Polson
Journal:  J Physiol       Date:  1975-01       Impact factor: 5.182

2.  Reversible inhibition of leucocyte sodium pumps by a circulating serum factor in essential hypertension.

Authors:  V M Oh; E A Taylor
Journal:  Br Med J (Clin Res Ed)       Date:  1986-06-14

3.  The effects of serum, lithium, ethacrynic acid, and a low external concentration of potassium on specific [3H]-ouabain binding to human lymphocytes after incubation for 3 days.

Authors:  W G Rapeport; J K Aronson; D G Grahame-Smith; C Harper
Journal:  Br J Clin Pharmacol       Date:  1986-09       Impact factor: 4.335

4.  Enhancement of specific [3H]ouabain binding and ouabain sensitive 86rubidium influx in intact human lymphocytes by a dialysable factor in human and fetal calf serum.

Authors:  V M Oh; E A Taylor; J L Ding; N A Boon; J K Aronson; D G Grahame-Smith
Journal:  Clin Sci (Lond)       Date:  1987-01       Impact factor: 6.124

5.  Defective genetic control of sodium-pump density in manic depressive psychosis.

Authors:  G J Naylor; A H Smith
Journal:  Psychol Med       Date:  1981-05       Impact factor: 7.723

6.  Measurement of specific [3H]-ouabain binding to different types of human leucocytes.

Authors:  N A Boon; V M Oh; E A Taylor; T Johansen; J K Aronson; D G Grahame-Smith
Journal:  Br J Clin Pharmacol       Date:  1984-08       Impact factor: 4.335

7.  Cation transport functions in vitro in patients with untreated essential hypertension: a comparison of erythrocytes and leucocytes.

Authors:  N A Boon; C Harper; J K Aronson; D G Grahame-Smith
Journal:  Clin Sci (Lond)       Date:  1985-05       Impact factor: 6.124
  7 in total
  5 in total

Review 1.  Pharmacokinetic optimisation of antiemetic therapy.

Authors:  M Campbell; D N Bateman
Journal:  Clin Pharmacokinet       Date:  1992-08       Impact factor: 6.447

2.  Pharmacokinetics of metoclopramide in patients with liver cirrhosis.

Authors:  E Magueur; H Hagege; P Attali; E Singlas; J P Etienne; A M Taburet
Journal:  Br J Clin Pharmacol       Date:  1991-02       Impact factor: 4.335

3.  Kinetics of intravenous metoclopramide in patients with hepatic cirrhosis.

Authors:  F Albani; M R Tamè; R De Palma; M Bernardi
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

Review 4.  Pharmacological Agents Affecting Emesis : A Review (Part II).

Authors:  F Mitchelson
Journal:  Drugs       Date:  1992-04       Impact factor: 9.546

Review 5.  Is metoclopramide beneficial for the postpyloric placement of nasoenteric tubes? A systematic review and meta-analysis of randomized controlled trials.

Authors:  Xin Ouyang; Rong Qu; Bei Hu; Yifan Wang; Fen Yao; Bo Lv; Cheng Sun; Yiyu Deng; Chunbo Chen
Journal:  Nutr Clin Pract       Date:  2021-06-22       Impact factor: 3.204
  5 in total

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