| Literature DB >> 31907561 |
Zhen Tan1,2,3,4, Jin Xu1,2,3,4, Bo Zhang1,2,3,4, Si Shi1,2,3,4, Xianjun Yu5,6,7,8, Chen Liang9,10,11,12.
Abstract
Pancreatic cancer (PC) remains one of the most extremely lethal malignancies worldwide due to late diagnosis and early metastasis, with a 1-year overall survival rate of approximately 20%. The hypoxic microenvironment, induced by intratumoral hypoxia, promotes tumor invasion and progression, leading to chemotherapy or radiotherapy resistance and eventual mortality after treatment of PC. However, the role of the hypoxic microenvironment in PC is complicated and requires further investigation. In this article, we review recent advances regarding the regulation of malignant behaviors in PC, which provide insight into the potential of hypoxic microenvironment activation therapy for the therapeutic agents.Entities:
Keywords: Chemoresistant; Hypoxia-inducible factors; Tumor malignant behavior
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Year: 2020 PMID： 31907561 DOI： 10.1007/s00018-019-03444-3
Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261