Mette Line Donneborg1,2, Bo Moelholm Hansen3, Pernille Kure Vandborg4, María Rodrigo-Domingo5,6, Finn Ebbesen4,7. 1. Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark. mld@rn.dk. 2. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. mld@rn.dk. 3. Department of Pediatrics, Herlev Hospital, Copenhagen, Denmark. 4. Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark. 5. Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark. 6. Psychiatry, Aalborg University Hospital, Aalborg, Denmark. 7. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Abstract
OBJECTIVE: To determine the incidence and etiology of extreme neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥450 µmol/L, and kernicterus spectrum disorder (KSD) in Denmark between 2000 and 2015. STUDY DESIGN: We identified all infants born between 01.01.2000 and 31.12.2015 with TSB ≥450 µmol/L, ratio of conjugated to TSB <0.30, gestational age ≥35 weeks, and postnatal age ≤4 weeks, using Danish hospitals' laboratory databases. RESULT: We included 408 infants. The incidence of extreme neonatal hyperbilirubinemia among infants with gestational age ≥35 weeks was 42/100,000 during the study period with a seemingly decreasing incidence between 2005 and 2015. Twelve of the 408 infants developed KSD, (incidence 1.2/100,000) Blood type ABO isohemolytic disease was the most common explanatory etiology. CONCLUSIONS: Our study stresses the importance of a systematic approach to neonatal jaundice and ongoing surveillance of extreme neonatal hyperbilirubinemia and KSD.
OBJECTIVE: To determine the incidence and etiology of extreme neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥450 µmol/L, and kernicterus spectrum disorder (KSD) in Denmark between 2000 and 2015. STUDY DESIGN: We identified all infants born between 01.01.2000 and 31.12.2015 with TSB ≥450 µmol/L, ratio of conjugated to TSB <0.30, gestational age ≥35 weeks, and postnatal age ≤4 weeks, using Danish hospitals' laboratory databases. RESULT: We included 408 infants. The incidence of extreme neonatal hyperbilirubinemia among infants with gestational age ≥35 weeks was 42/100,000 during the study period with a seemingly decreasing incidence between 2005 and 2015. Twelve of the 408 infants developed KSD, (incidence 1.2/100,000) Blood type ABO isohemolytic disease was the most common explanatory etiology. CONCLUSIONS: Our study stresses the importance of a systematic approach to neonatal jaundice and ongoing surveillance of extreme neonatal hyperbilirubinemia and KSD.
Authors: Berthe A M van der Geest; Malou J S de Mol; Ivana S A Barendse; Johanna P de Graaf; Loes C M Bertens; Marten J Poley; Erwin Ista; René F Kornelisse; Irwin K M Reiss; Eric A P Steegers; Jasper V Been Journal: Sci Rep Date: 2022-08-23 Impact factor: 4.996