Meiling Li1,2, Yong Shao2, Haiyan Fu2, Cheng Zhou2, Bing Yao2, Yong Tan1. 1. First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing 210029, China. 2. Reproductive Medicine Center, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210000, China.
Abstract
OBJECTIVE: To investigate the correlation between soluble receptor for advanced glycation end products (sRAGE) level in the follicular fluid and ovarian responsiveness in non-PCOS patients undergoing controlled ovarian hyperstimulation. METHODS: Ninety non-PCOS patients underwent IVF/ICSI using a short-acting long protocol for ovarian stimulation with a GnRH agonist. For each patient, the level of sRAGE in the follicular fluid was measured by enzyme linked immunosorbent assay (ELISA), and the data including the clinical baseline state, hormone level, number of oocytes obtained and the fertilization rate were collected. RESULTS: Follicular fluid sRAGE level showed significant negative correlations with basal FSH level (P=0.0036) and Gn dose (P < 0.0001) and positive correlations with AFC (P < 0.0001), number of oocytes obtained (P < 0.0001), and the fertilization rate (P=0.0047). Follicular fluid sRAGE level was positively correlated with the number of oocytes obtained, and was significantly higher in cases with oocytes obtained above the target number (> 15) than in cases with oocytes obtained within the range of the target numbers (7-15) and below the target number (< 7) (P < 0.0001 and P=0.0012, respectively). CONCLUSIONS: Follicular fluid sRAGE level can reflect ovarian reserve function in non-PCOS patients, the number of oocytes obtained and the fertilization rate, and can thus predict ovarian responsiveness during controlled hyperstimulation in nonPCOS patients.
OBJECTIVE: To investigate the correlation between soluble receptor for advanced glycation end products (sRAGE) level in the follicular fluid and ovarian responsiveness in non-PCOSpatients undergoing controlled ovarian hyperstimulation. METHODS: Ninety non-PCOSpatients underwent IVF/ICSI using a short-acting long protocol for ovarian stimulation with a GnRH agonist. For each patient, the level of sRAGE in the follicular fluid was measured by enzyme linked immunosorbent assay (ELISA), and the data including the clinical baseline state, hormone level, number of oocytes obtained and the fertilization rate were collected. RESULTS: Follicular fluid sRAGE level showed significant negative correlations with basal FSH level (P=0.0036) and Gn dose (P < 0.0001) and positive correlations with AFC (P < 0.0001), number of oocytes obtained (P < 0.0001), and the fertilization rate (P=0.0047). Follicular fluid sRAGE level was positively correlated with the number of oocytes obtained, and was significantly higher in cases with oocytes obtained above the target number (> 15) than in cases with oocytes obtained within the range of the target numbers (7-15) and below the target number (< 7) (P < 0.0001 and P=0.0012, respectively). CONCLUSIONS: Follicular fluid sRAGE level can reflect ovarian reserve function in non-PCOSpatients, the number of oocytes obtained and the fertilization rate, and can thus predict ovarian responsiveness during controlled hyperstimulation in nonPCOS patients.
Authors: Q T Huang; M Zhang; M Zhong; Y H Yu; W Z Liang; L L Hang; Y F Gao; L P Huang; Z J Wang Journal: Placenta Date: 2013-10-02 Impact factor: 3.481
Authors: J Neulen; Z Yan; S Raczek; K Weindel; C Keck; H A Weich; D Marmé; M Breckwoldt Journal: J Clin Endocrinol Metab Date: 1995-06 Impact factor: 5.958