Literature DB >> 3190692

Enhancement of intracellular calcium concentration by extracellular ATP and UTP in Madin Darby Canine Kidney cells.

M Paulmichl1, F Lang.   

Abstract

Fura2 - fluorescence was utilized to test for the effect of extracellular nucleotides on intracellular calcium concentration of subconfluent Madin-Darby Canine Kidney (MDCK)-cells. Extracellular ATP (10 mumol/l) and UTP (10 mumol/l) lead to rapid (within seconds), sustained, and fully reversible enhancement of intracellular calcium concentration from 138 +/- 9 nmol/l (n = 27), to 1561 +/- 260 nmol/l (n = 10) and 3435 +/- 949 nmol/l (n = 5), respectively. Half maximal effects are observed at some 1 mumol/l. In the absence of extracellular calcium the effect of ATP is transient, pointing to release of intracellular calcium. The sustained effect in the presence of extracellular calcium indicates that the nucleotides in addition recruit calcium from extracellular space.

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Year:  1988        PMID： 3190692     DOI： 10.1016/s0006-291x(88)80751-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

1.  Effect of bradykinin, ATP and adrenaline on cell membrane resistances of Madin-Darby canine kidney cells.

Authors:  M Ritter; F Lang
Journal:  J Physiol       Date:  1991-11       Impact factor: 5.182

2.  Hypoxia-inducible factor-1α causes renal cyst expansion through calcium-activated chloride secretion.

Authors:  Bjoern Buchholz; Gunnar Schley; Diana Faria; Sven Kroening; Carsten Willam; Rainer Schreiber; Bernd Klanke; Nicolai Burzlaff; Jonathan Jantsch; Karl Kunzelmann; Kai-Uwe Eckardt
Journal:  J Am Soc Nephrol       Date:  2013-11-07       Impact factor: 10.121

3.  Age dependence of tolerance to anoxia and changes in cytosolic calcium in rabbit renal proximal tubules.

Authors:  A R Constantinescu; R Rozental; M Barac-Nieto
Journal:  Pediatr Nephrol       Date:  1996-10       Impact factor: 3.714

4.  Fluorescence-optical measurements of chloride movements in cells using the membrane-permeable dye diH-MEQ.

Authors:  E Wöll; M Gschwentner; J Fürst; S Hofer; G Buemberger; A Jungwirth; J Frick; P Deetjen; M Paulmichl
Journal:  Pflugers Arch       Date:  1996-07       Impact factor: 3.657

5.  Regulation of ATP-induced calcium release in COS-7 cells by calcineurin.

Authors:  A Bandyopadhyay; D W Shin; D H Kim
Journal:  Biochem J       Date:  2000-05-15       Impact factor: 3.857

6.  Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P 2Y1 receptors, phospholipase A2 and protein kinase A.

Authors:  A Olga Akimova; Nathalie Bourcier; Sebastien Taurin; Richard A Bundey; Konrad Grygorczyk; Michael Gekle; Paul A Insel; Nickolai O Dulin; Sergei N Orlov
Journal:  J Physiol       Date:  2005-08-18       Impact factor: 5.182

7.  Antiviral drugs from the nucleoside analog family block volume-activated chloride channels.

Authors:  M Gschwentner; A Susanna; E Wöll; M Ritter; U O Nagl; A Schmarda; A Laich; G M Pinggera; H Ellemunter; H Huemer
Journal:  Mol Med       Date:  1995-05       Impact factor: 6.354

8.  Further analysis of ATP-mediated activation of K+ channels in renal epithelioid Madin Darby canine kidney (MDCK) cells.

Authors:  F Friedrich; H Weiss; M Paulmichl; E Wöll; S Waldegger; F Lang
Journal:  Pflugers Arch       Date:  1991-07       Impact factor: 3.657

9.  Effect of nucleotides on the cytosolic free calcium activity and inositol phosphate formation in human glomerular epithelial cells.

Authors:  H Pavenstädt; M Späth; G Schlunck; M Nauck; R Fischer; C Wanner; P Schollmeyer
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

10.  Blockade of swelling-induced chloride channels by phenol derivatives.

Authors:  M Gschwentner; A Jungwirth; S Hofer; E Wöll; M Ritter; A Susanna; A Schmarda; G Reibnegger; G M Pinggera; M Leitinger; J Frick; P Deetjen; M Paulmichl
Journal:  Br J Pharmacol       Date:  1996-05       Impact factor: 8.739
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