Literature DB >> 3190690

Octahedral complexes of anti-cancer Pt(IV)(cyclohexyldiamine) agents with 9-methylguanine.

H K Choi1, S K Huang, R Bau.   

Abstract

The compounds [Pt(IV)(dach)(9-methylguanine)2X2]2+ (X = Cl, OH) have been prepared and structurally characterized. Their existence shows that it is possible to accommodate two purine bases (in a cis configuration) and four other ligands around a Pt(IV) atom. The geometries of these complexes have very different orientations of the guanine rings as compared to their corresponding Pt(II) counterparts.

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Year:  1988        PMID: 3190690     DOI: 10.1016/s0006-291x(88)80749-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  1 in total

1.  Effects of N7-methylation, N7-platination, and C8-hydroxylation of guanine on H-bond formation with cytosine: platinum coordination strengthens the Watson-Crick pair.

Authors:  R K Sigel; E Freisinger; B Lippert
Journal:  J Biol Inorg Chem       Date:  2000-06       Impact factor: 3.862

  1 in total

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