Farida Benhadou1,2,3, Axel Patrice Villani4,5, Philippe Guillem6,7,8. 1. Department of Dermatology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. 2. ResoVerneuil, Paris, France. 3. European Hidradenitis Suppurativa Foundation e.V., Europe, Dessau, Germany. 4. Dermatology Department, Edouard Herriot Hospital, Hospices Civils de Lyon, Université Claude Bernard Lyon I, Lyon, France. 5. Groupe HS-France de la Société Française de Dermatologie, Paris, France. 6. ResoVerneuil, Paris, France, docteurphguillem@outlook.com. 7. European Hidradenitis Suppurativa Foundation e.V., Europe, Dessau, Germany, docteurphguillem@outlook.com. 8. Department of Surgery, Clinique du Val d'Ouest, Lyon, France, docteurphguillem@outlook.com.
Abstract
BACKGROUND: The factors that determine whether an area of the body will be affected by hidradenitis suppurativa (HS) are unknown. METHODS: To address these factors, we performed multivariate regression analyses in a cohort of 1,138 patients. RESULTS: We found that the body sites affected occurred in specific combinations that were influenced by sex and body mass index. We also revealed unexpected correlations between some sites and other comorbidities such as inflammatory diseases, acne conglobata, or dissecting folliculitis of the scalp. CONCLUSION: Such correlations are crucial to unravel a disease as variable as HS and identify pathophysiological mechanisms to enable the provision of personalized management.
BACKGROUND: The factors that determine whether an area of the body will be affected by hidradenitis suppurativa (HS) are unknown. METHODS: To address these factors, we performed multivariate regression analyses in a cohort of 1,138 patients. RESULTS: We found that the body sites affected occurred in specific combinations that were influenced by sex and body mass index. We also revealed unexpected correlations between some sites and other comorbidities such as inflammatory diseases, acne conglobata, or dissecting folliculitis of the scalp. CONCLUSION: Such correlations are crucial to unravel a disease as variable as HS and identify pathophysiological mechanisms to enable the provision of personalized management.