Hugo A Santos-Carvalho1,2, Manuel H Aguiar-Oliveira3, Roberto Salvatori4, Eugênia H O Valença5, Alana L Andrade-Guimarães1,2, Carlos E Palanch-Repeke1, Luan P Moreira-Cândido1, Carlos R Araújo-Daniel6, Aline C de Oliveira-Barreto1, Bruna M R Andrade5, Alaide H A Oliveira7, Edgar R Vieira8, Miburge B Gois-Junior1,2,6. 1. Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, 49060-100, Brazil. 2. Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (Grupo de Estudos em Atividade Física), Sergipe, Brazil. 3. Division of Endocrinology, Federal University of Sergipe, Aracaju, Sergipe, 49060-100, Brazil. 4. Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. salvator@jhmi.edu. 5. Department of Speech and Hearing Sciences, Federal University of Sergipe, Aracaju, Sergipe, 49060-100, Brazil. 6. Department of Statistic and Actuarial Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil. 7. Dentistry Division, Federal University of Sergipe, Aracaju, Sergipe, 49060-100, Brazil. 8. Department of Physical Therapy and Neuroscience, Wertheims' College of Nursing and Health Science, Florida International University, Florida City, FL, USA.
Abstract
PURPOSE: Body balance involves the vestibular, visual, and proprioceptive systems. IGF-I is a GH-dependent key factor in the development and postnatal differentiation of the inner ear in mice and men, but its role in the vestibular function in adult humans is unknown. We have previously described a cohort of individuals with severe isolated GH deficiency (IGHD) caused by a mutation in the GHRH receptor (GHRHR) gene. These individuals complain of dizziness, exhibit mild sensorineural loss, but have normal postural balance, without increase in falls risk. The aim of this study was to evaluate their vestibular function. METHODS: We performed physical examination (clinical head impulse and Fukuda dynamic stepping test), oculomotor (saccadic eye movements, spontaneous, semi-spontaneous and opotokinetic nystagmus, and pendular tracking) and caloric stimulation (postcaloric reflex and ocular fixation index) tests, in 15 GH-naïve IGHD (seven males) and 15 controls (five males). RESULTS: IGHD subjects showed lower height and weight, with similar BMI to controls, and higher number of individuals with abnormal clinical head impulse test and abnormal oculomotor tests, namely the saccadic movements and the spontaneous nystagmus. There was a nonsignificant trend in abnormalities in the Fukuda stepping test and postcaloric reflex test. CONCLUSIONS: Adult untreated IGHD individuals have higher prevalence of moderate peripheral vestibular impairment, and of abnormal vestibular-ocular reflex.
PURPOSE: Body balance involves the vestibular, visual, and proprioceptive systems. IGF-I is a GH-dependent key factor in the development and postnatal differentiation of the inner ear in mice and men, but its role in the vestibular function in adult humans is unknown. We have previously described a cohort of individuals with severe isolated GH deficiency (IGHD) caused by a mutation in the GHRH receptor (GHRHR) gene. These individuals complain of dizziness, exhibit mild sensorineural loss, but have normal postural balance, without increase in falls risk. The aim of this study was to evaluate their vestibular function. METHODS: We performed physical examination (clinical head impulse and Fukuda dynamic stepping test), oculomotor (saccadic eye movements, spontaneous, semi-spontaneous and opotokinetic nystagmus, and pendular tracking) and caloric stimulation (postcaloric reflex and ocular fixation index) tests, in 15 GH-naïve IGHD (seven males) and 15 controls (five males). RESULTS: IGHD subjects showed lower height and weight, with similar BMI to controls, and higher number of individuals with abnormal clinical head impulse test and abnormal oculomotor tests, namely the saccadic movements and the spontaneous nystagmus. There was a nonsignificant trend in abnormalities in the Fukuda stepping test and postcaloric reflex test. CONCLUSIONS: Adult untreated IGHD individuals have higher prevalence of moderate peripheral vestibular impairment, and of abnormal vestibular-ocular reflex.
Entities:
Keywords:
Electronystagmography; GH deficiency; IGF-I; Vestibular function
Authors: L M Frago; G Camerero; S Cañón; C Pañeda; C Sanz; Y Leon; F Giraldez; I Varela-Nieto Journal: Histol Histopathol Date: 2000-04 Impact factor: 2.303
Authors: R Salvatori; C Y Hayashida; M H Aguiar-Oliveira; J A Phillips; A H Souza; R G Gondo; S P Toledo; M M Conceicão; M Prince; H G Maheshwari; G Baumann; M A Levine Journal: J Clin Endocrinol Metab Date: 1999-03 Impact factor: 5.958