| Literature DB >> 31901503 |
Chao Yin1, Xiaozhen Li2, Guohua Wen3, Boguang Yang1, Yachao Zhang3, Xiaoyu Chen1, Pengchao Zhao1, Shengliang Li2, Rui Li1, Lidai Wang4, Chun-Sing Lee5, Liming Bian6.
Abstract
Development of near-infrared-II (NIR-II) light responsive nano-agents with high photothermal stability, high photothermal conversion efficiency (PCE), and excellent biocompatibility for photoacoustic (PA) imaging-guided photothermal therapy (PTT) is of tremendous significance. In spite of the superiority of organic semiconducting polymer nanoparticles (OSPNs) in PA imaging-guided PTT, the limited absorption in the first NIR (NIR-I) window and metastable nanostructure of OSPNs resulting from commonly used preparation methods based on nanoprecipitation or reprecipitation compromise their in vivo phototheranostic performance. Herein we design and synthesize a novel NIR-II absorbing organic semiconducting polymer amphiphile (OSPA) to enhance the structural stability of OSPNs. With prominent optical properties, low toxicity, and a suitable size, OSPA not only efficiently labels and kills cancer cells under NIR-II irradiation but also accumulates at the tumor of living mice upon intravenous injection, allowing efficient NIR-II light-triggered phototheranostics toward tumor. The developed OSPA has promising potential for fabricating multifunctional nanoplatforms to enable multimodal theranostics.Entities:
Keywords: Amphiphile; Photoacoustic imaging; Photothermal therapy; Second near-infrared window; Semiconducting polymer
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Year: 2019 PMID： 31901503 DOI： 10.1016/j.biomaterials.2019.119684
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479