Literature DB >> 31900813

"Cure" Versus "Clinical Remission": The Impact of a Medication Description on the Willingness of People Living with HIV to Take a Medication.

Ilona Fridman1, Peter A Ubel2,3,4, Jennifer Blumenthal-Barby5, Cameron V England6, Judith S Currier7, Nir Eyal8,9, Kenneth A Freedberg10,11,12,13, Scott D Halpern14, Colleen F Kelley15, Daniel R Kuritzkes9, Catherine N Le7, Jeffrey L Lennox6, Kathryn I Pollak16,17, Brian J Zikmund-Fisher18,19, Karen A Scherr3.   

Abstract

Many people living with HIV (PLWHIV) state that they would be willing to take significant risks to be "cured" of the virus. However, how they interpret the word "cure" in this context is not clear. We used a randomized survey to examine whether PLWHIV had a different willingness to take a hypothetical HIV medication if it causes flu-like symptoms, but provides: (a) cure, (b) remission that was labeled "cure", or (c) remission. PLWHIV (n = 454) were more willing to take a medication that provided a "cure" versus a "remission" if the side effects lasted less than 1 year. PLWHIV were more willing to take a medication that provided a remission that was labeled "cure" versus a "remission" (p = 0.01) if the side effects lasted 2 weeks. Clinicians and researchers should be aware of the impact of the word "cure" and ensure that PLWHIV fully understand the possible outcomes of their treatment options.

Entities:  

Keywords:  Behavior; Cure; Decision-making; HIV; PLWHIV; Remission

Mesh:

Year:  2020        PMID: 31900813      PMCID: PMC7319892          DOI: 10.1007/s10461-019-02769-1

Source DB:  PubMed          Journal:  AIDS Behav        ISSN: 1090-7165


  27 in total

1.  Challenges in clinical trial design for HIV-1 cure research.

Authors:  Nir Eyal; Daniel R Kuritzkes
Journal:  Lancet       Date:  2013-11-02       Impact factor: 79.321

2.  Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.

Authors:  Boris Julg; Lynda Dee; Jintanat Ananworanich; Dan H Barouch; Katharine Bar; Marina Caskey; Donn J Colby; Liza Dawson; Krista L Dong; Karine Dubé; Joseph Eron; John Frater; Rajesh T Gandhi; Romas Geleziunas; Philip Goulder; George J Hanna; Richard Jefferys; Rowena Johnston; Daniel Kuritzkes; Jonathan Z Li; Udom Likhitwonnawut; Jan van Lunzen; Javier Martinez-Picado; Veronica Miller; Luis J Montaner; Douglas F Nixon; David Palm; Giuseppe Pantaleo; Holly Peay; Deborah Persaud; Jessica Salzwedel; Karl Salzwedel; Timothy Schacker; Virginia Sheikh; Ole S Søgaard; Serena Spudich; Kathryn Stephenson; Jeremy Sugarman; Jeff Taylor; Pablo Tebas; Caroline T Tiemessen; Randall Tressler; Carol D Weiss; Lu Zheng; Merlin L Robb; Nelson L Michael; John W Mellors; Steven G Deeks; Bruce D Walker
Journal:  Lancet HIV       Date:  2019-03-15       Impact factor: 12.767

3.  Effect of "Pink Eye" Label on Parents' Intent to Use Antibiotics and Perceived Contagiousness.

Authors:  Laura D Scherer; Caitlin Finan; Dalton Simancek; Jerome I Finkelstein; Beth A Tarini
Journal:  Clin Pediatr (Phila)       Date:  2015-08-20       Impact factor: 1.168

4.  The ethics of HIV "cure" research: what can we learn from consent forms?

Authors:  Gail E Henderson
Journal:  AIDS Res Hum Retroviruses       Date:  2015-01       Impact factor: 2.205

5.  Financial Barriers and Lapses in Treatment and Care of HIV-Infected Adults in a Southern State in the United States.

Authors:  David A Wohl; Rita K Kuwahara; Kamran Javadi; Christine Kirby; David L Rosen; Sonia Napravnik; Claire Farel
Journal:  AIDS Patient Care STDS       Date:  2017-10-17       Impact factor: 5.078

6.  Experiences and expectations of participants completing an HIV cure focused clinical trial.

Authors:  James H McMahon; Julian H Elliott; Janine Roney; Michelle Hagenauer; Sharon R Lewin
Journal:  AIDS       Date:  2015-01-14       Impact factor: 4.177

7.  Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals.

Authors:  Ard I van Sighem; Luuk A J Gras; Peter Reiss; Kees Brinkman; Frank de Wolf
Journal:  AIDS       Date:  2010-06-19       Impact factor: 4.177

8.  If We Build It, Will They Come? Perceptions of HIV Cure-Related Research by People Living with HIV in Four U.S. Cities: A Qualitative Focus Group Study.

Authors:  Laurie Sylla; David Evans; Jeff Taylor; Adam Gilbertson; David Palm; Judith D Auerbach; Karine Dubé
Journal:  AIDS Res Hum Retroviruses       Date:  2018-01       Impact factor: 2.205

9.  What risk of death would people take to be cured of HIV and why? A survey of people living with HIV.

Authors:  Benjamin R Murray; Allison Kratka; Karen A Scherr; Nir Eyal; Jennifer Blumenthal-Barby; Kenneth A Freedberg; Daniel R Kuritzkes; James K Hammitt; Regina Edifor; Madelaine N Katz; Kathryn I Pollak; Brian J Zikmund-Fisher; Scott D Halpern; Mary C Barks; Peter A Ubel
Journal:  J Virus Erad       Date:  2019-04-01

10.  Interrupting antiretroviral treatment in HIV cure research: scientific and ethical considerations.

Authors:  Samual A Garner; Stuart Rennie; Jintanat Ananworanich; Karine Dube; David M Margolis; Jeremy Sugarman; Randall Tressler; Adam Gilbertson; Liza Dawson
Journal:  J Virus Erad       Date:  2017-04-01
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  3 in total

1.  Gain-loss framing and patients' decisions: a linguistic examination of information framing in physician-patient conversations.

Authors:  Ilona Fridman; Angela Fagerlin; Karen A Scherr; Laura D Scherer; Hanna Huffstetler; Peter A Ubel
Journal:  J Behav Med       Date:  2020-07-28

2.  Framing a Consent Form to Improve Consent Understanding and Determine How This Affects Willingness to Participate in HIV Cure Research: An Experimental Survey Study.

Authors:  John A Sauceda; Karine Dubé; Brandon Brown; Ashley E Pérez; Catherine E Rivas; David Evans; Celia B Fisher
Journal:  J Empir Res Hum Res Ethics       Date:  2020-12-14       Impact factor: 1.978

3.  The perceived impact of an HIV cure by people living with HIV and key populations vulnerable to HIV in the Netherlands: A qualitative study.

Authors:  Kim A G J Romijnders; Laura de Groot; Sigrid C J M Vervoort; Maartje G J Basten; Berend J van Welzen; Mirjam E Kretzschmar; Peter Reiss; Udi Davidovich; Ganna Rozhnova
Journal:  J Virus Erad       Date:  2022-02-25
  3 in total

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