Kah Poh Loh1, Paul Duberstein2, Jason Zittel3, Lianlian Lei4, Eva Culakova5, Huiwen Xu6, Sandy Plumb7, Marie A Flannery8, Allison Magnuson9, Javier Bautista10, Marsha Wittink11, Nikesha Gilmore12, Valerie Targia13, Alison Conlin14, Jeffrey Berenberg15, Victor G Vogel16, Supriya G Mohile17. 1. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: kahpoh_loh@urmc.rochester.edu. 2. Department of Health Behavior, Society, and Policy, Rutgers School of Public Health, New Brunswick, NJ, USA. Electronic address: paul_duberstein@rutgers.edu. 3. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: jason_zittel@urmc.rochester.edu. 4. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: lianlian_lei@urmc.rochester.edu. 5. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: eva_culakova@urmc.rochester.edu. 6. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: huiwen_xu@urmc.rochester.edu. 7. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: sandy_plumb@urmc.rochester.edu. 8. School of Nursing, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: marie_flannery@urmc.rochester.edu. 9. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: allison_magnuson@urmc.rochester.edu. 10. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: javier_bautista@urmc.rochester.edu. 11. Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: marsha_wittink@urmc.rochester.edu. 12. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: nikesha_gilmore@urmc.rochester.edu. 13. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. 14. Pacific Cancer Research Consortium National Cancer Institute Community Oncology Research Program (NCORP), Seattle, WA, USA. Electronic address: alison.conlin@providence.org. 15. Hawaii National Cancer Institute Community Oncology Research Program (MU-NCORP), Honolulu, HI, USA. Electronic address: berenber@hawaii.edu. 16. Geisinger Cancer Institute NCORP, Danville, PA, USA. Electronic address: vgvogel@geisinger.edu. 17. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: supriya_mohile@urmc.rochester.edu.
Abstract
OBJECTIVES: Older self-perceived age is associated with poor health and higher healthcare utilization in the geriatric population. We evaluated the associations of self-perceived age with geriatric assessment (GA) domain impairments in older adults with cancer. METHODS: This was a secondary analysis of baseline data from a GA cluster-randomized trial (URCC 13070; PI: Mohile). We included patients aged ≥70 with incurable stage III/IV solid tumor or lymphoma considering or receiving treatment and had ≥1 GA domain impairment other than polypharmacy. Multivariate analyses were used to evaluate the associations of age difference between chronological and self-perceived age (categorized into "feeling younger than chronological age" vs. "feeling the same or older than their chronological age") with GA domain impairments. RESULTS: We included 533 patients; mean age was 76.6 (SD 5.2). On multivariate analyses, compared to those who felt younger than their chronological age, those who felt the same or older were more likely to have impairments in physical performance [Adjusted Odds Ratio (AOR) 5.42, 95% Confidence Interval (CI) 1.69-17.40)], functional status (AOR 2.31, 95% CI 1.73-3.07), comorbidity (AOR 1.62, 95% CI 1.20-2.19), psychological health (AOR 2.62, 95% CI 1.85-3.73), and nutrition (AOR 1.65, 95% CI 1.20-2.28). They were also more likely to screen positively for polypharmacy (AOR 1.86, 95% CI 1.30-2.65). CONCLUSIONS: Older adults with cancer who felt the same or older than their chronological age were more likely to have GA domain impairments. Further studies are needed to better understand the relationships between self-perceived age, aging-related conditions, and outcomes in this population.
OBJECTIVES: Older self-perceived age is associated with poor health and higher healthcare utilization in the geriatric population. We evaluated the associations of self-perceived age with geriatric assessment (GA) domain impairments in older adults with cancer. METHODS: This was a secondary analysis of baseline data from a GA cluster-randomized trial (URCC 13070; PI: Mohile). We included patients aged ≥70 with incurable stage III/IV solid tumor or lymphoma considering or receiving treatment and had ≥1 GA domain impairment other than polypharmacy. Multivariate analyses were used to evaluate the associations of age difference between chronological and self-perceived age (categorized into "feeling younger than chronological age" vs. "feeling the same or older than their chronological age") with GA domain impairments. RESULTS: We included 533 patients; mean age was 76.6 (SD 5.2). On multivariate analyses, compared to those who felt younger than their chronological age, those who felt the same or older were more likely to have impairments in physical performance [Adjusted Odds Ratio (AOR) 5.42, 95% Confidence Interval (CI) 1.69-17.40)], functional status (AOR 2.31, 95% CI 1.73-3.07), comorbidity (AOR 1.62, 95% CI 1.20-2.19), psychological health (AOR 2.62, 95% CI 1.85-3.73), and nutrition (AOR 1.65, 95% CI 1.20-2.28). They were also more likely to screen positively for polypharmacy (AOR 1.86, 95% CI 1.30-2.65). CONCLUSIONS: Older adults with cancer who felt the same or older than their chronological age were more likely to have GA domain impairments. Further studies are needed to better understand the relationships between self-perceived age, aging-related conditions, and outcomes in this population.
Authors: Arti Hurria; Kayo Togawa; Supriya G Mohile; Cynthia Owusu; Heidi D Klepin; Cary P Gross; Stuart M Lichtman; Ajeet Gajra; Smita Bhatia; Vani Katheria; Shira Klapper; Kurt Hansen; Rupal Ramani; Mark Lachs; F Lennie Wong; William P Tew Journal: J Clin Oncol Date: 2011-08-01 Impact factor: 44.544
Authors: Kah Poh Loh; Supriya G Mohile; Ronald M Epstein; Colin McHugh; Marie Flannery; Eva Culakova; Lianlian Lei; Megan Wells; Nikesha Gilmore; Dilip Babu; Mary I Whitehead; William Dale; Arti Hurria; Marsha Wittink; Allison Magnuson; Alison Conlin; Melanie Thomas; Jeffrey Berenberg; Paul R Duberstein Journal: Cancer Date: 2019-03-28 Impact factor: 6.860
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Authors: Kah Poh Loh; Enrique Soto-Perez-de-Celis; Tina Hsu; Nienke A de Glas; Nicolò Matteo Luca Battisti; Capucine Baldini; Manuel Rodrigues; Stuart M Lichtman; Hans Wildiers Journal: J Oncol Pract Date: 2018-02 Impact factor: 3.714
Authors: Víctor Manuel Mendoza-Núñez; Elia Sarmiento-Salmorán; Regulo Marín-Cortés; María de la Luz Martínez-Maldonado; Mirna Ruiz-Ramos Journal: J Clin Med Date: 2018-05-07 Impact factor: 4.241