| Literature DB >> 31898700 |
Weiqi Zhang1, Bo Han2, Xinning Lai2, Chen Xiao3, Shilin Xu2, Xianghui Meng2, Zifu Li4, Jie Meng2, Tao Wen2, Xiangliang Yang4, Jian Liu2, Haiyan Xu2.
Abstract
Here we demonstrated that the stiffness of cationized gelatin nanoparticles determined the efficiency of RNAi in myeloid leukemia cells when the particle size and surface charges were kept constant. The siRNA delivery system with an elastic modulus of 0.87 MPa showed the largest siRNA uptake and RNAi efficiency for hard-to-transfect suspension cells.Entities:
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Year: 2020 PMID： 31898700 DOI： 10.1039/c9cc09068a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222