Literature DB >> 31898609

Ozone and oxidation therapies as a solution to the emerging crisis in infectious disease management: a review of current knowledge and experience.

Robert Jay Rowen1.   

Abstract

Medicine faces crisis with emerging "super bugs," lethal viruses (Ebola), and stealth pathogens such as tick-borne infections. Thousands are dying worldwide of once easily treatable diseases. Ozone therapy, extensively studied, may be a valuable adjunctive or stand-alone therapy. Ebola again ravages Africa with over 2000 already dead, carrying a 65% mortality rate. The world desperately needs safe, inexpensive and effective anti-infective therapy to which microbes will not develop resistance. Oxidation therapies have shown an extremely high safety profile, lacking credible reports of significant injury beyond vein irritation. Ozone therapy, the most studied and least expensive to perform, is in itself a germicide, not an antibiotic, and improves several physiological parameters essential for infection defense. Recent reports indicate very favorable responses to both bacterial and viral disease, inclusive of Ebola. Despite lack of commercial profitability (not patentable), medicine would do well to revisit its pre-antibiotic era oxidation therapy roots, especially ozone in the current crisis.

Entities:  

Keywords:  Ebola; Lyme disease; antibiotic; antimicrobial; antiviral; biofilm; germicide; immune modulation; infection therapy; ozone therapy

Mesh:

Substances:

Year:  2019        PMID: 31898609     DOI: 10.4103/2045-9912.273962

Source DB:  PubMed          Journal:  Med Gas Res        ISSN: 2045-9912


  10 in total

1.  The antimicrobial effect of different ozone protocols applied in severe curved canals contaminated with Enterococcus faecalis: ex vivo study.

Authors:  Mariana Montagner Moraes; Marcelo Santos Coelho; Wayne Martins Nascimento; Carlos Goes Nogales; Francisco Ubiratan Ferreira de Campos; Adriana de Jesus Soares; Marcos Frozoni
Journal:  Odontology       Date:  2021-01-28       Impact factor: 2.634

Review 2.  Ozone (O3) and SARS-CoV-2: Physiological Bases and Their Therapeutic Possibilities According to COVID-19 Evolutionary Stage.

Authors:  Marcos Edgar Fernández-Cuadros; María Jesús Albaladejo-Florín; Daiana Peña-Lora; Sandra Álava-Rabasa; Olga Susana Pérez-Moro
Journal:  SN Compr Clin Med       Date:  2020-07-07

3.  Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study).

Authors:  Mili Shah; Jignasha Captain; Vidyadhar Vaidya; Arvind Kulkarni; Kedar Valsangkar; Pradeep M K Nair; Gayatri Ganu
Journal:  Int Immunopharmacol       Date:  2020-12-23       Impact factor: 5.714

4.  Blood ozonization in patients with mild to moderate COVID-19 pneumonia: a single centre experience.

Authors:  Carlo Tascini; Giovanni Sermann; Alberto Pagotto; Emanuela Sozio; Chiara De Carlo; Alessandro Giacinta; Francesco Sbrana; Andrea Ripoli; Nadia Castaldo; Maria Merelli; Barbara Cadeo; Cristiana Macor; Amato De Monte
Journal:  Intern Emerg Med       Date:  2020-11-01       Impact factor: 3.397

Review 5.  Deceptology in cancer and vaccine sciences: Seeds of immune destruction-mini electric shocks in mitochondria: Neuroplasticity-electrobiology of response profiles and increased induced diseases in four generations - A hypothesis.

Authors:  Mahin Khatami
Journal:  Clin Transl Med       Date:  2020-12

Review 6.  HIF-1, the Warburg Effect, and Macrophage/Microglia Polarization Potential Role in COVID-19 Pathogenesis.

Authors:  Elisabetta Ferraro; Maria Germanò; Rocco Mollace; Vincenzo Mollace; Natalia Malara
Journal:  Oxid Med Cell Longev       Date:  2021-03-12       Impact factor: 6.543

7.  A pilot study for treatment of COVID-19 patients in moderate stage using intravenous administration of ozonized saline as an adjuvant treatment-registered clinical trial.

Authors:  Alok Sharma; Mili Shah; Satya Lakshmi; Hemangi Sane; Jignasha Captain; Nandini Gokulchandran; Pallavi Khubchandani; M K Pradeep; Prakash Gote; Balaji Tuppekar; Pooja Kulkarni; Amruta Paranjape; Radhika Pradhan; Ritu Varghese; Sushil Kasekar; Vivek Nair; Ummeammara Khanbande
Journal:  Int Immunopharmacol       Date:  2021-04-30       Impact factor: 5.714

Review 8.  Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges.

Authors:  Ross D Zafonte; Lei Wang; Christian A Arbelaez; Rachel Dennison; Yang D Teng
Journal:  Adv Sci (Weinh)       Date:  2022-03-04       Impact factor: 17.521

9.  Ozone dialysis delivers three or more times the ozone than other forms of ozone blood treatment.

Authors:  Robert Jay Rowen; Sharon Grabovac; Teresa B Su
Journal:  Med Gas Res       Date:  2023 Apr-Jun

Review 10.  Environmental Disinfection of a Dental Clinic during the Covid-19 Pandemic: A Narrative Insight.

Authors:  Antonio Scarano; Francesco Inchingolo; Felice Lorusso
Journal:  Biomed Res Int       Date:  2020-10-28       Impact factor: 3.411

  10 in total

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