Silvia Pereira1, Carlos Saboya2, Andrea Ramalho3. 1. Federal University of Rio de Janeiro (UFRJ), Rua Dona Mariana, 143/F11, Botafogo, Rio de Janeiro, RJ, 22280-020, Brazil. se.pereira@gmail.com. 2. Federal University of São Paulo (UNIFESP), São Paulo, Brazil. 3. Federal University of Rio de Janeiro (UFRJ), Rua Dona Mariana, 143/F11, Botafogo, Rio de Janeiro, RJ, 22280-020, Brazil.
Abstract
BACKGROUND: To assess the relationship of body composition measures and basal metabolic rate (BMR) with gastrointestinal hormones in weight regain 5 years after gastric bypass. METHODS: A total of 42 patients were divided into two groups: with and without weight regain 5 years after gastric bypass. Hormone assessments were performed after a fasting period and at 30, 60, and 120 min after the standard meal intake. RESULTS: Patients with no weight regain had significantly lower visceral fat (VF), lower fat body mass (FBM), and lower fat percentage (%F) in relation to the other group. In the group without weight regain, at baseline, glucose-dependent insulinotropic polypeptide (GIP) showed a negative correlation with weight and BMI and a positive correlation with BMR, skeletal muscle mass (SMM), and fat-free mass (FFM). After the standard meal, the following results were found: a negative correlation with %F, a positive correlation of glucagon-like peptide-1 (GLP-1) with FFM, and a positive correlation of GLP-2 and PYY with BMR, SMM, and FFM. In the group with weight regain, at baseline, GIP, PYY, and GLP-1 showed a negative correlation with %F. After the standard meal, PYY and GLP-1 showed a negative correlation with VF, FBM, and %F. On the other hand, GLP-2 negatively correlated with VF and FBM. CONCLUSION: It is possible to conclude that there is a different relationship of concentrations of PYY, GIP, GLP-1, and GLP-2 with body composition and BMR in patients with and without weight regain in the late gastric bypass postoperative period.
BACKGROUND: To assess the relationship of body composition measures and basal metabolic rate (BMR) with gastrointestinal hormones in weight regain 5 years after gastric bypass. METHODS: A total of 42 patients were divided into two groups: with and without weight regain 5 years after gastric bypass. Hormone assessments were performed after a fasting period and at 30, 60, and 120 min after the standard meal intake. RESULTS:Patients with no weight regain had significantly lower visceral fat (VF), lower fat body mass (FBM), and lower fat percentage (%F) in relation to the other group. In the group without weight regain, at baseline, glucose-dependent insulinotropic polypeptide (GIP) showed a negative correlation with weight and BMI and a positive correlation with BMR, skeletal muscle mass (SMM), and fat-free mass (FFM). After the standard meal, the following results were found: a negative correlation with %F, a positive correlation of glucagon-like peptide-1 (GLP-1) with FFM, and a positive correlation of GLP-2 and PYY with BMR, SMM, and FFM. In the group with weight regain, at baseline, GIP, PYY, and GLP-1 showed a negative correlation with %F. After the standard meal, PYY and GLP-1 showed a negative correlation with VF, FBM, and %F. On the other hand, GLP-2 negatively correlated with VF and FBM. CONCLUSION: It is possible to conclude that there is a different relationship of concentrations of PYY, GIP, GLP-1, and GLP-2 with body composition and BMR in patients with and without weight regain in the late gastric bypass postoperative period.
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