E Guazzo1,2, B Panizza3,4,5. 1. Queensland Skull Base Unit, Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia. 2. Faculty of Medicine, University of Queensland, Brisbane, Australia. 3. Queensland Skull Base Unit, Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia. b.panizza@uq.edu.au. 4. Faculty of Medicine, University of Queensland, Brisbane, Australia. b.panizza@uq.edu.au. 5. Department of Neurosciences, Mater Hospital of Brisbane, South Brisbane, Australia. b.panizza@uq.edu.au.
Abstract
INTRODUCTION: This article provides an overview of the natural history and management of adenoid cystic carcinoma infiltrating the skull base (SB ACC). METHODS: A comprehensive review of the available literature and discussion regarding the current management of SB ACC. RESULTS: This review describes the unique pathology, appropriate diagnostic work-up and contemporary management options in SB ACC. There is a specific focus on the role of surgical resection with post-operative radiotherapy, given the literature suggesting a superior locoregional control rate. The importance of surgical decision making and varying surgical approaches are detailed. In addition, the emerging role of biological agents is discussed. CONCLUSION: The gold standard for SB ACC is surgical resection and post-operative radiation, given the superior locoregional control. In patients not amendable to surgery, palliative radiation should be considered. The role of biological agents is still evolving. The complexity of SB ACC management mandates experienced multi-speciality management.
INTRODUCTION: This article provides an overview of the natural history and management of adenoid cystic carcinoma infiltrating the skull base (SB ACC). METHODS: A comprehensive review of the available literature and discussion regarding the current management of SB ACC. RESULTS: This review describes the unique pathology, appropriate diagnostic work-up and contemporary management options in SB ACC. There is a specific focus on the role of surgical resection with post-operative radiotherapy, given the literature suggesting a superior locoregional control rate. The importance of surgical decision making and varying surgical approaches are detailed. In addition, the emerging role of biological agents is discussed. CONCLUSION: The gold standard for SB ACC is surgical resection and post-operative radiation, given the superior locoregional control. In patients not amendable to surgery, palliative radiation should be considered. The role of biological agents is still evolving. The complexity of SB ACC management mandates experienced multi-speciality management.
Entities:
Keywords:
Adenoid cystic carcinoma; Anterior skull base; Central skull base; Head and neck cancer; Lateral skull base; Radiotherapy; Skull base surgery
Authors: Othman Bin-Alamer; Ali S Haider; Adhiraj Chaudhary; Kishore Balasubramanian; Tessa Breeding; Paolo Palmisciano; Maryam Haider; Aaron A Cohen-Gadol; Tarek Y El Ahmadieh; Kenny Yu Journal: Cancer Diagn Progn Date: 2022-09-03
Authors: Sara Ronchi; Barbara Vischioni; Maria Bonora; Amelia Barcellini; Laura D Locati; Paolo Castelnuovo; Piero Nicolai; Cesare Piazza; Mohssen Ansarin; Marco Benazzo; Ester Orlandi Journal: Oral Oncol Date: 2020-05-14 Impact factor: 5.337