Takahisa Yamasaki1, Sasan Sakiani1, Carla Maradey-Romero1, Ripple Mehta1, Dalbir Sandhu1, Stephen Ganocy2, Colin Hemond1, Mohamed Eisa3, Ronnie Fass4. 1. Division of Gastroenterology and Hepatology, MetroHealth Medical Center, The Esophageal and Swallowing Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. 2. Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA. 3. Department of Internal Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA. 4. Division of Gastroenterology and Hepatology, MetroHealth Medical Center, The Esophageal and Swallowing Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. ronnie.fass@gmail.com.
Abstract
BACKGROUND: Barrett's esophagus (BE), a complication of long-term gastroesophageal reflux disease (GERD), has been reported to affect 6-8% of those with heartburn. Most patients are males, Caucasians and middle aged. However, there are no recent demographic studies that evaluated the proportion trends of BE. We aimed to assess proportion trends of BE over an 11-year period, using a very large national dataset. METHODS: This was a population-based analysis of the national Explorys dataset. Explorys is an aggregate of electronic medical record database representing over 54 million patients. Proportions of BE's variables such as age, gender, race, BMI, and treatment with PPI were recorded during an 11-year period. BE patients were classified into seven age groups (15-19, 20-29, 30-39, 40-49, 50-59, 60-69, ≥ 70 years old). Secular trends of the proportion of BE were assessed over time for each age group. RESULTS: The majority of patients diagnosed with BE were ≥ 70 years old across all calendar years. However, the proportion of BE patients who were ≥ 70 years old has significantly decreased between 2006 and 2016 (- 19.9%, p < 0.001). The proportion of patients with BE increased in all age groups but most prominently in the age groups, 30-39: 2.07%, 40-49: 3.64%, 50-59: 6.89%, 60-69: 6.18%, p < 0.001. BE was significantly more common in those who were Caucasian and male. PPI usage fell significantly in those who were ≥ 70 years old (- 20.8%, p < 0.001), but increased in the other remaining age groups. CONCLUSIONS: The proportion of BE patients who are 70 years and older has significantly dropped. Younger patients' groups have demonstrated the highest increase in the proportion of BE patients, especially those in the age group of 30-39 years old.
BACKGROUND:Barrett's esophagus (BE), a complication of long-term gastroesophageal reflux disease (GERD), has been reported to affect 6-8% of those with heartburn. Most patients are males, Caucasians and middle aged. However, there are no recent demographic studies that evaluated the proportion trends of BE. We aimed to assess proportion trends of BE over an 11-year period, using a very large national dataset. METHODS: This was a population-based analysis of the national Explorys dataset. Explorys is an aggregate of electronic medical record database representing over 54 million patients. Proportions of BE's variables such as age, gender, race, BMI, and treatment with PPI were recorded during an 11-year period. BEpatients were classified into seven age groups (15-19, 20-29, 30-39, 40-49, 50-59, 60-69, ≥ 70 years old). Secular trends of the proportion of BE were assessed over time for each age group. RESULTS: The majority of patients diagnosed with BE were ≥ 70 years old across all calendar years. However, the proportion of BEpatients who were ≥ 70 years old has significantly decreased between 2006 and 2016 (- 19.9%, p < 0.001). The proportion of patients with BE increased in all age groups but most prominently in the age groups, 30-39: 2.07%, 40-49: 3.64%, 50-59: 6.89%, 60-69: 6.18%, p < 0.001. BE was significantly more common in those who were Caucasian and male. PPI usage fell significantly in those who were ≥ 70 years old (- 20.8%, p < 0.001), but increased in the other remaining age groups. CONCLUSIONS: The proportion of BEpatients who are 70 years and older has significantly dropped. Younger patients' groups have demonstrated the highest increase in the proportion of BEpatients, especially those in the age group of 30-39 years old.
Entities:
Keywords:
Age; Barrett’s esophagus; Epidemiology; PPI
Authors: M Conio; A J Cameron; Y Romero; C D Branch; C D Schleck; L J Burgart; A R Zinsmeister; L J Melton; G R Locke Journal: Gut Date: 2001-03 Impact factor: 23.059
Authors: Hashem B El-Serag; Ali Hashmi; Jose Garcia; Peter Richardson; Abeer Alsarraj; Stephanie Fitzgerald; Marcelo Vela; Yasser Shaib; Neena S Abraham; Maria Velez; Rhonda Cole; Margot B Rodriguez; Bhupinderjit Anand; David Y Graham; Jennifer R Kramer Journal: Gut Date: 2013-02-13 Impact factor: 23.059
Authors: Joel H Rubenstein; Hal Morgenstern; William D Chey; Joseph Murray; James M Scheiman; Philip Schoenfeld; Henry D Appelman; Laurence McMahon; Val Metko; Joan Kellenberg; Tal Kalish; Jason Baker; John M Inadomi Journal: Gut Date: 2013-03-05 Impact factor: 23.059
Authors: Jennifer M Kolb; Samuel Han; Frank I Scott; Caitlin C Murphy; Patrick Hosokawa; Sachin Wani Journal: Gastroenterology Date: 2020-08-08 Impact factor: 33.883