Literature DB >> 31894418

6-Hydroxydopamine: a far from simple neurotoxin.

Damir Varešlija1,2, Keith F Tipton3, Gavin P Davey1, Andrew G McDonald1.   

Abstract

6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson's disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species. Its ability to release Fe(II) from protein storage sites also results in the formation of hROS. This account will consider how this family of toxic products may contribute to the observed effects of 6-OHDA.

Entities:  

Keywords:  4-Hydroxynonenal; Aminochrome; Apoptosis; Autoxidation; Dopamine; Highly reactive oxygen species (hROS); Iron release; Mitochondria; Necrosis; Neurotoxicity; Oxidative damage; Parkinson’s disease; Peroxynitrite; Reactive oxygen species (ROS)

Year:  2020        PMID： 31894418     DOI： 10.1007/s00702-019-02133-6

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  185 in total

Review 1.  Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds.

Authors:  K F Tipton; T P Singer
Journal:  J Neurochem       Date:  1993-10       Impact factor: 5.372

2.  6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat.

Authors:  Débora F Gonçalves; Aline A Courtes; Diane D Hartmann; Pamela C da Rosa; Débora M Oliveira; Félix A A Soares; Cristiane L Dalla Corte
Journal:  Neurotoxicology       Date:  2018-10-22       Impact factor: 4.294

3.  Dopamine Oxidation Products as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson's Disease.

Authors:  Alice Biosa; Irene Arduini; Maria Eugenia Soriano; Valentina Giorgio; Paolo Bernardi; Marco Bisaglia; Luigi Bubacco
Journal:  ACS Chem Neurosci       Date:  2018-07-03       Impact factor: 4.418

4.  The reaction of ozone with glyceraldehyde-3-phosphate dehydrogenase.

Authors:  K L Knight; J B Mudd
Journal:  Arch Biochem Biophys       Date:  1984-02-15       Impact factor: 4.013

5.  Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein.

Authors:  Marco Bisaglia; Stefano Mammi; Luigi Bubacco
Journal:  J Biol Chem       Date:  2007-03-29       Impact factor: 5.157

Review 6.  The 6-hydroxydopamine model: news from the past.

Authors:  Fabio Blandini; Marie-Therese Armentero; Emilia Martignoni
Journal:  Parkinsonism Relat Disord       Date:  2008-07-02       Impact factor: 4.891

7.  Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson's disease.

Authors:  Mona Sadeghian; Gizem Mullali; Jennifer M Pocock; Thomas Piers; Arthur Roach; Kenneth J Smith
Journal:  Neuropathol Appl Neurobiol       Date:  2015-09-25       Impact factor: 8.090

Review 8.  Use and abuse of exogenous H2O2 in studies of signal transduction.

Authors:  Henry Jay Forman
Journal:  Free Radic Biol Med       Date:  2007-01-12       Impact factor: 7.376

9.  Kinetic evidence that cysteine reacts with dopaminoquinone via reversible adduct formation to yield 5-cysteinyl-dopamine: an important precursor of neuromelanin.

Authors:  Guy N L Jameson; Jie Zhang; Reginald F Jameson; Wolfgang Linert
Journal:  Org Biomol Chem       Date:  2004-02-11       Impact factor: 3.876

Review 10.  Impaired dopamine metabolism in Parkinson's disease pathogenesis.

Authors:  Anna Masato; Nicoletta Plotegher; Daniela Boassa; Luigi Bubacco
Journal:  Mol Neurodegener       Date:  2019-08-20       Impact factor: 14.195
View more
  2 in total

1.  Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in C. elegans and Cellular Models of Parkinson's Disease.

Authors:  Tao Long; Qian Wu; Jing Wei; Yong Tang; Yan-Ni He; Chang-Long He; Xue Chen; Lu Yu; Chong-Lin Yu; Betty Yuen-Kwan Law; Jian-Ming Wu; Da-Lian Qin; An-Guo Wu; Xiao-Gang Zhou
Journal:  Oxid Med Cell Longev       Date:  2022-02-22       Impact factor: 6.543

Review 2.  Sympathetic Nerves and Innate Immune System in the Spleen: Implications of Impairment in HIV-1 and Relevant Models.

Authors:  Denise L Bellinger; Dianne Lorton
Journal:  Cells       Date:  2022-02-15       Impact factor: 6.600
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.