Hiroko Watanabe1, Shinichiro Okauchi2, Hideyasu Yamada3, Shinya Sato4, Kunihiko Miyazaki4, Takahide Kodama4, Hiroaki Satoh5, Nobuyuki Hizawa6. 1. Division of Respiratory Medicine, Tsukuba Kinen General Hospital, Tsukuba, Japan. 2. Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Japan. 3. Division of Respiratory Medicine, Hitachinaka Medical Center, University of Tsukuba-Hitachinaka General Hospital, Hitachinaka, Japan. 4. Division of Respiratory Medicine, Ryugasaki Saiseikai General Hospital, Ryugasaki, Japan. 5. Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Japan hirosato@md.tsukuba.ac.jp. 6. Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Abstract
BACKGROUND/AIM: In patients with lung cancer, there has been no study that treated 'distant metastases' as 'metastatic patterns'. This study aimed to evaluate if specific 'metastatic patterns' exist in lung cancer patients. PATIENTS AND METHODS: Data were collected from lung cancer patients between 2009 and 2018. Metastatic patterns were analyzed using cluster analysis in patients with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma, those with small cell lung cancer (SCLC), and those with squamous cell lung cancer (SqCLC). RESULTS: In 313 patients (127 patients with EGFR mutation, 87 patients with SCLC, and 99 patients with SqCLC), metastatic patterns existed in each of the three subset groups, and metastatic patterns of these groups were statistically different. CONCLUSION: The knowledge of the metastatic patterns might be useful for clinical practice in the foreseeable future, as it enables a more efficient detection of metastatic disease through imaging, and a more effective treatment at predicted metastatic sites. Copyright
BACKGROUND/AIM: In patients with lung cancer, there has been no study that treated 'distant metastases' as 'metastatic patterns'. This study aimed to evaluate if specific 'metastatic patterns' exist in lung cancerpatients. PATIENTS AND METHODS: Data were collected from lung cancerpatients between 2009 and 2018. Metastatic patterns were analyzed using cluster analysis in patients with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma, those with small cell lung cancer (SCLC), and those with squamous cell lung cancer (SqCLC). RESULTS: In 313 patients (127 patients with EGFR mutation, 87 patients with SCLC, and 99 patients with SqCLC), metastatic patterns existed in each of the three subset groups, and metastatic patterns of these groups were statistically different. CONCLUSION: The knowledge of the metastatic patterns might be useful for clinical practice in the foreseeable future, as it enables a more efficient detection of metastatic disease through imaging, and a more effective treatment at predicted metastatic sites. Copyright