Takashi Kijima1, Takaaki Arigami2, Yoshikazu Uenosono3, Tsubasa Hiraki4, Shigehiro Yanagita3, Daisuke Matsushita3, Keishi Okubo3, Masataka Shimonosono3, Sumiya Ishigami3, Kosei Maemura3, Akihide Tanimoto4, Shoji Natsugoe3,2. 1. Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan ta@m2.kufm.kagoshima-u.ac.jp. 2. Department of Bio-oncological Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. 3. Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. 4. Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Abstract
BACKGROUND/AIM: The aim of the present study was to compare human epidermal growth factor receptor 2 (HER2) expression before and after trastuzumab-based chemotherapy in patients with advanced HER2-positive gastric cancer. MATERIALS AND METHODS: We assessed HER2 expression using immunohistochemistry and/or fluorescence in situ hybridization in pre-treatment biopsied specimens and post-treatment resected specimens obtained from seven patients with advanced HER2-positive gastric cancer receiving trastuzumab-based chemotherapy. RESULTS: Four patients maintained the HER2-positive status and three patients had a change in HER2 expression from positive to negative. In patients showing the loss of HER2 expression after treatments, HER2-positive tumor cells with a dominant histological type disappeared, and HER2-negative tumor cells with another dominant histological type were identified. CONCLUSION: HER2 expression can change after trastuzumab-based chemotherapy in patients with advanced HER2-positive gastric cancer. Continuous monitoring of HER2 expression after treatments may be utilized to determine whether the continued use of trastuzumab is advisable. Copyright
BACKGROUND/AIM: The aim of the present study was to compare humanepidermal growth factor receptor 2 (HER2) expression before and after trastuzumab-based chemotherapy in patients with advanced HER2-positive gastric cancer. MATERIALS AND METHODS: We assessed HER2 expression using immunohistochemistry and/or fluorescence in situ hybridization in pre-treatment biopsied specimens and post-treatment resected specimens obtained from seven patients with advanced HER2-positive gastric cancer receiving trastuzumab-based chemotherapy. RESULTS: Four patients maintained the HER2-positive status and three patients had a change in HER2 expression from positive to negative. In patients showing the loss of HER2 expression after treatments, HER2-positive tumor cells with a dominant histological type disappeared, and HER2-negative tumor cells with another dominant histological type were identified. CONCLUSION:HER2 expression can change after trastuzumab-based chemotherapy in patients with advanced HER2-positive gastric cancer. Continuous monitoring of HER2 expression after treatments may be utilized to determine whether the continued use of trastuzumab is advisable. Copyright
Authors: G Roviello; M Catalano; L F Iannone; L Marano; M Brugia; G Rossi; G Aprile; L Antonuzzo Journal: Clin Transl Oncol Date: 2022-01-29 Impact factor: 3.405
Authors: Nicole M Myer; Kohei Shitara; Hyun C Chung; Florian Lordick; Ronan J Kelly; Zsolt Szabo; Z Alexander Cao; Stephen Leong; David H Ilson; Wilko Weichert Journal: J Cancer Res Clin Oncol Date: 2022-05-13 Impact factor: 4.322
Authors: Giandomenico Roviello; Giuseppe Aprile; Alberto D'Angelo; Luigi Francesco Iannone; Franco Roviello; Karol Polom; Enrico Mini; Martina Catalano Journal: Gastric Cancer Date: 2021-03-19 Impact factor: 7.370