Niels Michael Dörr1, Michael Bartels2, Mehmet Haluk Morgul3. 1. Department of General, Visceral, Thoracic and Vascular Surgery, Helios Park-Klinikum Leipzig, Leipzig, Germany nielsdoerr@gmail.com. 2. Department of General, Visceral, Thoracic and Vascular Surgery, Helios Park-Klinikum Leipzig, Leipzig, Germany. 3. Department of General, Visceral and Transplantation Surgery, University of Münster, Münster, Germany.
Abstract
BACKGROUND/AIM: The treatment of colorectal liver metastases is challenging and requires multidisciplinary strategies. Unfortunately, only 25% of patients with colorectal liver metastases are eligible for liver resection. Due to the variety of therapeutic approaches, this percentage has increased; however, at the same time, the definition of resectability has become complex. The aim of this review was to provide an overview of current surgical therapies for colorectal liver metastases. MATERIALS AND METHODS: Relevant studies published before June 2019 were identified using PubMed. A comprehensive review of the current literature regarding the impact of and innovations in the therapy of colorectal liver metastases was carried out. RESULTS: The major advances in the resectability of colorectal liver metastases were effective chemotherapy regimens and preoperative liver volume modulation techniques. In addition, health professionals face rapid technical developments in interventional local therapies, minimally invasive surgery, robot-assisted surgery and even liver transplantation. CONCLUSION: Currently, liver metastases from colorectal cancer are considered a chronic disease. In cases of advanced colorectal liver metastases, the definition of resectability and the indications for surgical treatment should be exclusively determined by experienced hepatobiliary surgeons. Copyright
BACKGROUND/AIM: The treatment of colorectal liver metastases is challenging and requires multidisciplinary strategies. Unfortunately, only 25% of patients with colorectal liver metastases are eligible for liver resection. Due to the variety of therapeutic approaches, this percentage has increased; however, at the same time, the definition of resectability has become complex. The aim of this review was to provide an overview of current surgical therapies for colorectal liver metastases. MATERIALS AND METHODS: Relevant studies published before June 2019 were identified using PubMed. A comprehensive review of the current literature regarding the impact of and innovations in the therapy of colorectal liver metastases was carried out. RESULTS: The major advances in the resectability of colorectal liver metastases were effective chemotherapy regimens and preoperative liver volume modulation techniques. In addition, health professionals face rapid technical developments in interventional local therapies, minimally invasive surgery, robot-assisted surgery and even liver transplantation. CONCLUSION: Currently, liver metastases from colorectal cancer are considered a chronic disease. In cases of advanced colorectal liver metastases, the definition of resectability and the indications for surgical treatment should be exclusively determined by experienced hepatobiliary surgeons. Copyright
Authors: David Schöler; Mirco Castoldi; Markus S Jördens; Max Schulze-Hagen; Christiane Kuhl; Verena Keitel; Tom Luedde; Christoph Roderburg; Sven H Loosen Journal: PLoS One Date: 2021-08-18 Impact factor: 3.240
Authors: Vladislav Treska; Jan Bruha; Vaclav Liska; Jakub Fichtl; Kristyna Prochazkova; Tereza Petrakova; Petr Hosek Journal: In Vivo Date: 2020 Sep-Oct Impact factor: 2.155
Authors: Sven H Loosen; Max Schulze-Hagen; Mihael Vucur; Joao Gorgulho; Pia Paffenholz; Fabian Benz; Raphael Mohr; Münevver Demir; Alexander Wree; Christiane Kuhl; Christian Trautwein; Frank Tacke; Philipp Bruners; Tom Luedde; Christoph Roderburg Journal: JGH Open Date: 2021-02-01
Authors: Shadi Katou; Franziska Schmid; Carolina Silveira; Lina Schäfer; Tizian Naim; Felix Becker; Sonia Radunz; Mazen A Juratli; Leon Louis Seifert; Hauke Heinzow; Benjamin Struecker; Andreas Pascher; M Haluk Morgul Journal: J Clin Med Date: 2022-03-29 Impact factor: 4.241
Authors: Moritz T Winkelmann; Rami Archid; Georg Gohla; Gerald Hefferman; Jens Kübler; Jakob Weiss; Stephan Clasen; Konstantin Nikolaou; Silvio Nadalin; Rüdiger Hoffmann Journal: Cancer Imaging Date: 2020-05-27 Impact factor: 3.909
Authors: Theresa H Wirtz; Sven H Loosen; Max Schulze-Hagen; Joao Gorgulho; Jennis Kandler; Markus Joerdens; Münevver Demir; Raphael Mohr; Philipp Bruners; Christiane Kuhl; Christian Trautwein; Marie-Luise Berres; Frank Tacke; Tom Luedde; Christoph Roderburg Journal: Clin Transl Sci Date: 2021-07-19 Impact factor: 4.689