| Literature DB >> 31889735 |
Myles W Smith1, Isaac D Falk1, Hideya Ikemoto1, Noah Z Burns1.
Abstract
Pyrroloiminoquinone alkaloids represent a structurally intriguing class of natural products that display an array of useful biological properties. Here, we present a versatile and scalable platform for the synthesis of this diverse family - and in particular the antitumor discorhabdins - built upon sequential selective C-H functionalization of tryptamine. The utility of this strategy is showcased through short formal syntheses of damirones A-C, makaluvamines D and I, and discorhadbin E. Additionally, we describe efforts to develop the first catalytic asymmetric entry to the discorhabdin subclass.Entities:
Year: 2019 PMID： 31889735 PMCID： PMC6937132 DOI： 10.1016/j.tet.2019.05.009
Source DB: PubMed Journal: Tetrahedron ISSN： 0040-4020 Impact factor: 2.457