Dynamic analysis of a fractional-order delayed model for hepatitis B virus with CTL immune response.

In this paper, a fractional-order delayed model with Holling II functional response and CTL immune response is constructed to describe the transmission of hepatitis B virus. Firstly, the existence and uniqueness of positive solutions are proved. Secondly, the basic reproduction number and the sufficient conditions for the existence of three equilibriums are obtained. Thirdly, the stability of three equilibriums are investigated. In addition, some sufficient conditions for the occurrence of Hopf bifurcation near the endemic equilibrium are demonstrated by using time delay as the bifurcation parameter. After that, some numerical simulations are performed to verify the theoretical prediction. At last, a brief discussion is presented to end this paper.