| Literature DB >> 318860 |
H A de Boer, W J Weyer, J G de Boer, S van der Heide, M Gruber.
Abstract
The synthesis of ppGpp in spoT- mutants of Escherichia coli has been invesitgated. In these mutants the first-order rate constant for ppGpp breakdown is low, and pppGpp is barely detectable. It is shown that the rate of pppGpp, and hence ppGpp, synthesis is strongly reduced compared with that observed in spot+ strains. The low rate of magic spot synthesis satisfactorily explains the low levels of pppGpp in spoT- mutants. The pentaphosphate very probably is the precursor of ppGpp as it is in wild-type, i.e. spoT+, strains.Entities:
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Year: 1977 PMID： 318860 DOI： 10.1016/0005-2787(77)90190-3
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002