Edward G Lakatta1, Danilo AlunniFegatelli2, Christopher H Morrell3, Edoardo Fiorillo4, Marco Orru4, Alessandro Delitala4, Michele Marongiu4, David Schlessinger5, Francesco Cucca6, Angelo Scuteri7. 1. Laboratory of Cardiovascular Sciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD. 2. Department of Public Health and Infectious Disease, University "La Sapienza", Rome, Italy. 3. Laboratory of Cardiovascular Sciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD; Loyola University Maryland, Baltimore, MD. 4. Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delel Ricerche, Lanusei, Sardinia, Italy. 5. Laboratory of Genetics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD. 6. Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delel Ricerche, Cagliari, Italy. 7. Department of Medical, Surgical, and Experimental Sciences, University of Sassari, Sassari, Italy. Electronic address: ascuteri@uniss.it.
Abstract
OBJECTIVES: Carotid-femoral pulse wave velocity (PWV), an index of arterial stiffness and a proxy of arterial aging, has been reported to be an independent determinant of cardiovascular health. Whether the effects of antihypertensive treatment vary in the presence of accelerated arterial aging (stiffer artery, ie, PWV >10 m/s) has not been established. We tested this hypothesis in a longitudinal study in a large community-dwelling population. DESIGN: Longitudinal population study with repeated measures. SETTING AND PARTICIPANTS: Study population consisted of a cohort of 6011 volunteers (2546 men and 3465 women, age range 14-101 years; 15,011 observations over a median follow-up of 6.8 years) participating in the SardiNIA Study. MEASURES: Repeated measures of PWV, blood pressure (BP), and metabolic risk factors and the antihypertensive medication trajectories of BP and PWV over time were assessed via mixed effects models. RESULTS: Antihypertensive treatment significantly affected the trajectory of BP in both participants with (-0.47 ± 0.20 mmHg/y, P = .02) and participants without stiffer arteries (-0.47 ± 0.07 mmHg/y, P = .001). They also affected the trajectory of PWV in participants with stiffer artery, independent of the BP values. CONCLUSIONS AND IMPLICATIONS: Antihypertensive treatment is effective in reducing both BP and PWV in older individuals with stiffer arteries.
OBJECTIVES: Carotid-femoral pulse wave velocity (PWV), an index of arterial stiffness and a proxy of arterial aging, has been reported to be an independent determinant of cardiovascular health. Whether the effects of antihypertensive treatment vary in the presence of accelerated arterial aging (stiffer artery, ie, PWV >10 m/s) has not been established. We tested this hypothesis in a longitudinal study in a large community-dwelling population. DESIGN: Longitudinal population study with repeated measures. SETTING AND PARTICIPANTS: Study population consisted of a cohort of 6011 volunteers (2546 men and 3465 women, age range 14-101 years; 15,011 observations over a median follow-up of 6.8 years) participating in the SardiNIA Study. MEASURES: Repeated measures of PWV, blood pressure (BP), and metabolic risk factors and the antihypertensive medication trajectories of BP and PWV over time were assessed via mixed effects models. RESULTS: Antihypertensive treatment significantly affected the trajectory of BP in both participants with (-0.47 ± 0.20 mmHg/y, P = .02) and participants without stiffer arteries (-0.47 ± 0.07 mmHg/y, P = .001). They also affected the trajectory of PWV in participants with stiffer artery, independent of the BP values. CONCLUSIONS AND IMPLICATIONS: Antihypertensive treatment is effective in reducing both BP and PWV in older individuals with stiffer arteries.
Authors: Weiwei Zeng; Tanya T W Chu; Chung Shun Ho; Clara W S Lo; Alan S L Chan; Alice P S Kong; Brian Tomlinson; Sze Wa Chan Journal: Front Cardiovasc Med Date: 2022-04-01
Authors: Agne Laucyte-Cibulskiene; Chen-Huan Chen; John Cockroft; Pedro G Cunha; Maryam Kavousi; Aleksandras Laucevicius; Maria Lorenza Muiesan; Ernst R Rietzschel; Ligita Ryliskyte; Irina D Strazhesko; Charalambos Vlachopoulos; Jorge Cotter; Ekatherina N Dudinskaya; Nichola Gale; Fariba Ahmadizar; Francesco U S Mattace-Raso; Maggie Munnery; Pedro Oliveira; Anna Paini; Massimo Salvetti; Olga N Tkacheva; Edward G Lakatta; Peter M Nilsson; Angelo Scuteri Journal: Sci Rep Date: 2022-08-24 Impact factor: 4.996