Yu-Cheng Hsieh1, Yun-Yu Chen2, Kuo-Liong Chien3, Fa-Po Chung4, Li-Wei Lo4, Shih-Lin Chang4, Tze-Fan Chao4, Yu-Feng Hu4, Chin-Yu Lin4, Ta-Chuan Tuan4, Jo-Nan Liao4, Yenn-Jiang Lin5, Shih-Ann Chen4. 1. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan. Electronic address: ychsieh@vghtc.gov.tw. 2. Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. 3. Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. 4. Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. 5. Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: yjlin3@vghtpe.gov.tw.
Abstract
BACKGROUND: Atrial fibrillation (AF) is associated with increased risks of dementia and hospitalization. Whether catheter ablation (CA) for AF might reduce such risks remains unclear. We aimed to investigate the effects of CA on dementia and hospitalization risks during a very long-term follow-up. METHODS: We studied a total of 787 AF patients receiving CA for AF treatment from 2003 to 2012 (AF CA group). The propensity score of this group was matched to another two cohorts: (a) AF patients without CA (AF no CA, n = 787) and (b) control patients without AF (n = 770). New onset of dementia of each subject was identified by ICD-9-CM codes, and information on hospitalization for AF was based on medical records. The Cox proportional hazards model was used to determine the hazard ratios (HRs) for events. RESULTS: During 9.0 ± 2.6 year's follow-up, a total of 139 dementia events and 732 AF-related hospitalizations have occurred. AF CA group has lower incidence of dementia than AF no CA group (adjusted HR: 0.44, p = 0.005). AF related hospitalizations were also lower in the AF CA group than that in AF no CA group (adjusted HR: 0.72, p < 0.05). In AF patients aged >65 years, CA reduced the risk of dementia compared to those without CA (adjusted HR: 0.46, p = 0.03). CONCLUSIONS: In a 9-year follow-up, we found that CA had reduced the risk of dementia and hospitalization in AF patients, compared with those without CA. Such reduction in the risk of dementia was particularly clear in older AF patients (aged >65 years).
BACKGROUND:Atrial fibrillation (AF) is associated with increased risks of dementia and hospitalization. Whether catheter ablation (CA) for AF might reduce such risks remains unclear. We aimed to investigate the effects of CA on dementia and hospitalization risks during a very long-term follow-up. METHODS: We studied a total of 787 AFpatients receiving CA for AF treatment from 2003 to 2012 (AF CA group). The propensity score of this group was matched to another two cohorts: (a) AFpatients without CA (AF no CA, n = 787) and (b) control patients without AF (n = 770). New onset of dementia of each subject was identified by ICD-9-CM codes, and information on hospitalization for AF was based on medical records. The Cox proportional hazards model was used to determine the hazard ratios (HRs) for events. RESULTS: During 9.0 ± 2.6 year's follow-up, a total of 139 dementia events and 732 AF-related hospitalizations have occurred. AF CA group has lower incidence of dementia than AF no CA group (adjusted HR: 0.44, p = 0.005). AF related hospitalizations were also lower in the AF CA group than that in AF no CA group (adjusted HR: 0.72, p < 0.05). In AFpatients aged >65 years, CA reduced the risk of dementia compared to those without CA (adjusted HR: 0.46, p = 0.03). CONCLUSIONS: In a 9-year follow-up, we found that CA had reduced the risk of dementia and hospitalization in AFpatients, compared with those without CA. Such reduction in the risk of dementia was particularly clear in older AFpatients (aged >65 years).
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