Literature DB >> 31883994

Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets.

Kenneth W Finnson1, Yasser Almadani1, Anie Philip2.   

Abstract

Transforming growth factor (TGF)-β uses several intracellular signaling pathways besides canonical ALK5-Smad2/3 signaling to regulate a diverse array of cellular functions. Several of these so-called non-canonical (non-Smad2/3) pathways have been implicated in the pathogenesis of fibrosis and may therefore represent targets for therapeutic intervention. This review summarizes our current knowledge on the mechanisms of non-canonical TGF-β signaling in fibrosis, the potential molecular targets and the use of agonists/antagonists for therapeutic intervention.
Copyright © 2019. Published by Elsevier Ltd.

Entities:  

Keywords:  Fibrosis; Non-nanonical; Scleroderma; TGF-beta; non-Smad

Year:  2019        PMID： 31883994     DOI： 10.1016/j.semcdb.2019.11.013

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  26 in total

1.  Combined control of the fibroblast contractile program by YAP and TAZ.

Authors:  Patrick A Link; Kyoung Moo Choi; Ana M Diaz Espinosa; Dakota L Jones; Ashley Y Gao; Andrew J Haak; Daniel J Tschumperlin
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2021-11-10       Impact factor: 5.464

Review 2.  Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH).

Authors:  Xiaohan Xu; Kyle L Poulsen; Lijuan Wu; Shan Liu; Tatsunori Miyata; Qiaoling Song; Qingda Wei; Chenyang Zhao; Chunhua Lin; Jinbo Yang
Journal:  Signal Transduct Target Ther       Date:  2022-08-13

Review 3.  Wound Healing: A Comprehensive Review.

Authors:  Yasser H Almadani; Joshua Vorstenbosch; Peter G Davison; Amanda M Murphy
Journal:  Semin Plast Surg       Date:  2021-07-15       Impact factor: 2.195

4.  DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition.

Authors:  Xia Guo; Oluwaseun Adeyanju; Christudas Sunil; Venkatakirankumar Mandlem; Ayobami Olajuyin; Steven Huang; Shi-You Chen; Steven Idell; Torry A Tucker; Guoqing Qian
Journal:  Am J Physiol Cell Physiol       Date:  2022-05-18       Impact factor: 5.282

Review 5.  TGFβ as a gatekeeper of BMP action in the developing growth plate.

Authors:  Weiguang Wang; Diana Rigueur; Karen M Lyons
Journal:  Bone       Date:  2020-05-20       Impact factor: 4.626

6.  Orai1 Channel Regulates Human-Activated Pancreatic Stellate Cell Proliferation and TGFβ1 Secretion through the AKT Signaling Pathway.

Authors:  Silviya Radoslavova; Antoine Folcher; Thibaut Lefebvre; Kateryna Kondratska; Stéphanie Guénin; Isabelle Dhennin-Duthille; Mathieu Gautier; Natalia Prevarskaya; Halima Ouadid-Ahidouch
Journal:  Cancers (Basel)       Date:  2021-05-15       Impact factor: 6.639

7.  Fermented Rice Bran Supplementation Prevents the Development of Intestinal Fibrosis Due to DSS-Induced Inflammation in Mice.

Authors:  Afifah Zahra Agista; Tubagus Bahtiar Rusbana; Jahidul Islam; Yusuke Ohsaki; Halima Sultana; Ryouta Hirakawa; Kouichi Watanabe; Tomonori Nochi; Slamet Budijanto; Suh-Ching Yang; Takuya Koseki; Hisashi Aso; Michio Komai; Hitoshi Shirakawa
Journal:  Nutrients       Date:  2021-05-30       Impact factor: 5.717

Review 8.  The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney.

Authors:  Craig E Higgins; Jiaqi Tang; Stephen P Higgins; Cody C Gifford; Badar M Mian; David M Jones; Wenzheng Zhang; Angelica Costello; David J Conti; Rohan Samarakoon; Paul J Higgins
Journal:  Front Cell Dev Biol       Date:  2021-07-02

Review 9.  Dissecting the Involvement of Ras GTPases in Kidney Fibrosis.

Authors:  José M Muñoz-Félix; Carlos Martínez-Salgado
Journal:  Genes (Basel)       Date:  2021-05-24       Impact factor: 4.096

10.  TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis.

Authors:  Shizan Xu; Yuqing Mao; Jianye Wu; Jiao Feng; Jingjing Li; Liwei Wu; Qiang Yu; Yuting Zhou; Jie Zhang; Jiaojiao Chen; Jie Ji; Kan Chen; Fan Wang; Weiqi Dai; Xiaoming Fan; Chuanyong Guo
Journal:  J Cell Mol Med       Date:  2020-03-31       Impact factor: 5.310
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