Quantitative estimation of increased vascular permeability in acute inflammatory reaction in the chicken skin.

An increase in vascular permeability was estimated quantitatively in acute inflammatory reaction in the chicken using passive cutaneous anaphylaxis as an experimental model. Dye exuded in the cutaneous lesion was extracted by formamide and measured spectrophotometrically. The technique, though time-consuming, worked well in the chicken. The results suggested that the method can be profitably utilised in studies relating to avian inflammation.