Literature DB >> 31883706

Single cell sequencing shines a light on malaria parasite relatedness in complex infections.

Sasha V Siegel1, Julian C Rayner2.   

Abstract

Recent genomic studies are investigating the wide-ranging implications of malaria complex infections on parasite diversity, transmission, and downstream disease eradication efforts. Using single cell sequencing, new work by Nkhoma et al. provides evidence that there is unexpectedly frequent co-transmission of related parasites in the intense transmission setting in Malawi.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  co-transmission; complexity of infection (COI); malaria; relatedness; single cell sequencing; superinfection

Mesh:

Year:  2020        PMID: 31883706     DOI: 10.1016/j.pt.2019.12.007

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN: 1471-4922


  1 in total

1.  Identity-by-descent with uncertainty characterises connectivity of Plasmodium falciparum populations on the Colombian-Pacific coast.

Authors:  Aimee R Taylor; Diego F Echeverry; Timothy J C Anderson; Daniel E Neafsey; Caroline O Buckee
Journal:  PLoS Genet       Date:  2020-11-16       Impact factor: 5.917

  1 in total

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