Measurement by spectrophotometer of blood cholinesterases inactivation following single oral doses of phosphamidon in Bubalus bubalis.

The effect of phosphamidon on blood cholinesterases (ChE) was investigated in male buffalo calves following single oral doses of 20, 40 and 80 mg/kg body wt. Phosphamidon at all 3 doses levels significantly inactivated erythrocyte and plasma ChE (66-98 and 67-89%, respectively) within 8-12 hr of administration. The inhibition was dose dependent, and the extent of inactivation of blood ChE correlated well with severity of toxicity following all phosphamidon doses.