Saco J de Visser1, Adam F Cohen2, Marcel J H Kenter3. 1. The Netherlands Organisation for Health Research and Development (ZonMw), The Hague, the Netherlands. visser@zonmw.nl. 2. Centre for Human Drug Research (CHDR InnoS), Leiden, the Netherlands. 3. Paul Janssen Futurelab, Leiden University Medical Center, Leiden, the Netherlands.