BACKGROUND/AIM: The number of older patients with colorectal cancer (CRC) is increasing. Stage II CRC is a heterogeneous group of cancers with different prognoses. We aimed to examine older patients in relation to clinical outcome following curative resection in stage II CRC. PATIENTS AND METHODS: We analyzed data for 329 consecutive patients with stage II CRC following curative resection. Recurrence-free survival (RFS) and overall survival (OS) were compared between older patients ≥75 years of age and those <75 years. Cox proportional hazards model was used to compute hazard ratios (HRs) controlling for potential confounders. RESULTS: In the multivariable analyses, patients ≥75 years were independently associated with shorter RFS (multivariable HR=2.56, 95% confidence interval (CI)=1.55-4.31, p<0.001) and OS (multivariable HR=4.36, 95%CI=2.08-9.97, p<0.001) in stage II CRC. CONCLUSION: Older patients were independently associated with shorter RFS and OS following curative resection in stage II CRC. Copyright
BACKGROUND/AIM: The number of older patients with colorectal cancer (CRC) is increasing. Stage II CRC is a heterogeneous group of cancers with different prognoses. We aimed to examine older patients in relation to clinical outcome following curative resection in stage II CRC. PATIENTS AND METHODS: We analyzed data for 329 consecutive patients with stage II CRC following curative resection. Recurrence-free survival (RFS) and overall survival (OS) were compared between older patients ≥75 years of age and those <75 years. Cox proportional hazards model was used to compute hazard ratios (HRs) controlling for potential confounders. RESULTS: In the multivariable analyses, patients ≥75 years were independently associated with shorter RFS (multivariable HR=2.56, 95% confidence interval (CI)=1.55-4.31, p<0.001) and OS (multivariable HR=4.36, 95%CI=2.08-9.97, p<0.001) in stage II CRC. CONCLUSION: Older patients were independently associated with shorter RFS and OS following curative resection in stage II CRC. Copyright
Authors: Dirk L Kienle; Daniel Dietrich; Karin Ribi; Andreas Wicki; Luca Quagliata; Ralph C Winterhalder; Dieter Koeberle; Daniel Horber; Sara Bastian; Marc Kueng; Piercarlo Saletti; Daniel Helbling; Daniela Baertschi; Alessandro Lugli; Juerg Bernhard; Christiane Andrieu; Roger von Moos Journal: J Geriatr Oncol Date: 2018-12-14 Impact factor: 3.599
Authors: X Filella; R Molina; J J Grau; J M Piqué; J C Garcia-Valdecasas; E Astudillo; A Biete; J M Bordas; A Novell; E Campo Journal: Ann Surg Date: 1992-07 Impact factor: 12.969
Authors: Qian Shi; Thierry Andre; Axel Grothey; Greg Yothers; Stanley R Hamilton; Brian M Bot; Daniel G Haller; Eric Van Cutsem; Chris Twelves; Jacqueline K Benedetti; Michael J O'Connell; Daniel J Sargent Journal: J Clin Oncol Date: 2013-08-26 Impact factor: 44.544