Angela Diamantopoulou1, Dimitrios Mantas1, Ioannis D Kostakis2, George Agrogiannis3, Zoe Garoufalia1, Nikolaos Kavantzas3, Gregory Kouraklis1. 1. Second Department of Propaedeutic Surgery, "Laiko" General Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece. 2. Second Department of Propaedeutic Surgery, "Laiko" General Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece i.d.kostakis@gmail.com. 3. First Department of Pathology, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Abstract
BACKGROUND/AIM: The calcium-binding protein S100A14 is involved in processes related to tumorigenesis and tumor propagation, such as proliferation, apoptosis, motility and invasiveness. Our aim was to investigate its role in colorectal cancer. PATIENTS AND METHODS: One hundred and seven patients (65 men and 42 women) were included in this study. They had been diagnosed with colorectal cancer and undergone complete resection of their primary tumor. Tissue samples from archival blocks of their normal and malignant colorectal tissues were used for immunohistochemical assessment of S100A14 expression. S100A14 levels were evaluated using image analysis and associated with various clinicopathological parameters and prognosis. RESULTS: S100A14 expression was reduced in malignant tissues when compared to normal intestinal mucosa in cases of T3-T4 tumors (p=0.017). Moreover, as far as S100A14 levels in malignant tissues are concerned, they were lower in T3-T4 tumors (p=0.001), N2 disease (p=0.034) and M1 disease (p=0.019). Finally, very high S100A14 production (>75th percentile) was associated with shorter disease-specific (HR=3.584, p=0.045) and relapse-free survival (HR=4.527, p=0.007) in multivariate survival analysis. CONCLUSION: S100A14 expression is decreased in advanced colorectal cancer. However, cases with very high S100A14 levels have a worse survival. Copyright
BACKGROUND/AIM: The calcium-binding protein S100A14 is involved in processes related to tumorigenesis and tumor propagation, such as proliferation, apoptosis, motility and invasiveness. Our aim was to investigate its role in colorectal cancer. PATIENTS AND METHODS: One hundred and seven patients (65 men and 42 women) were included in this study. They had been diagnosed with colorectal cancer and undergone complete resection of their primary tumor. Tissue samples from archival blocks of their normal and malignant colorectal tissues were used for immunohistochemical assessment of S100A14 expression. S100A14 levels were evaluated using image analysis and associated with various clinicopathological parameters and prognosis. RESULTS:S100A14 expression was reduced in malignant tissues when compared to normal intestinal mucosa in cases of T3-T4 tumors (p=0.017). Moreover, as far as S100A14 levels in malignant tissues are concerned, they were lower in T3-T4 tumors (p=0.001), N2 disease (p=0.034) and M1 disease (p=0.019). Finally, very high S100A14 production (>75th percentile) was associated with shorter disease-specific (HR=3.584, p=0.045) and relapse-free survival (HR=4.527, p=0.007) in multivariate survival analysis. CONCLUSION:S100A14 expression is decreased in advanced colorectal cancer. However, cases with very high S100A14 levels have a worse survival. Copyright
Authors: Dipak Sapkota; Ove Bruland; Daniela Elena Costea; Hallvard Haugen; Endre N Vasstrand; Salah O Ibrahim Journal: Eur J Cancer Date: 2010-11-10 Impact factor: 9.162
Authors: Sidse Ehmsen; Lea Tykgaard Hansen; Martin Bak; Charlotte Brasch-Andersen; Henrik J Ditzel; Rikke Leth-Larsen Journal: Int J Cancer Date: 2015-05-21 Impact factor: 7.396
Authors: Paula Moravkova; Darina Kohoutova; Stanislav Rejchrt; Jiri Cyrany; Jan Bures Journal: Gastroenterol Res Pract Date: 2016-01-06 Impact factor: 2.260