X Li1, X Li1, J Li2, X Jiao1, X Jia1, X Zhang1, G Fan1, J Yang3, J Guo4. 1. Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi province, PR China. 2. GE Healthcare, Computed Tomography Research Center, Beijing, 100176, PR China. 3. Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi province, PR China. Electronic address: yj1118@mail.xjtu.edu.cn. 4. Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi province, PR China. Electronic address: xjyjsz@163.com.
Abstract
AIM: To compare bone mineral density (BMD) measurement accuracy by dual-energy spectral computed tomography (CT) and quantitative CT (QCT) using an anthropomorphic European spine phantom (ESP). MATERIALS AND METHODS: An ESP containing three hydroxyapatite inserts with densities of 50, 100, and 200 mg/cm3 was scanned 10 times each using spectral CT and QCT protocols. Their BMD values were measured using hydroxyapatite-based spectral CT material decomposition images and QCT images and compared with the true values in ESP. RESULTS: Both protocols had good repeatability in BMD measurement with low coefficient-of-variance (spectral CT: <2.31%; QCT: <1.17%). There were biases in BMD measurement for the 50, 100, and 200 mg/cm3 hydroxyapatite insert with relative errors of 2.34% (48.83±1.13 mg/cm3), 2% (98±1.25 mg/cm3) and 5.96% (188.09±2.11 mg/cm3), in spectral CT, and 11% (55.5±0.65 mg/cm3), 9.85% (109.85±0.42 mg/cm3) and 4.04% (208.07±0.54 mg/cm3) in QCT, respectively. CONCLUSION: BMD can be accurately measured using either QCT or spectral CT, and spectral CT has smaller bias than QCT.
AIM: To compare bone mineral density (BMD) measurement accuracy by dual-energy spectral computed tomography (CT) and quantitative CT (QCT) using an anthropomorphic European spine phantom (ESP). MATERIALS AND METHODS: An ESP containing three hydroxyapatite inserts with densities of 50, 100, and 200 mg/cm3 was scanned 10 times each using spectral CT and QCT protocols. Their BMD values were measured using hydroxyapatite-based spectral CT material decomposition images and QCT images and compared with the true values in ESP. RESULTS: Both protocols had good repeatability in BMD measurement with low coefficient-of-variance (spectral CT: <2.31%; QCT: <1.17%). There were biases in BMD measurement for the 50, 100, and 200 mg/cm3 hydroxyapatite insert with relative errors of 2.34% (48.83±1.13 mg/cm3), 2% (98±1.25 mg/cm3) and 5.96% (188.09±2.11 mg/cm3), in spectral CT, and 11% (55.5±0.65 mg/cm3), 9.85% (109.85±0.42 mg/cm3) and 4.04% (208.07±0.54 mg/cm3) in QCT, respectively. CONCLUSION: BMD can be accurately measured using either QCT or spectral CT, and spectral CT has smaller bias than QCT.
Authors: Vitali Koch; Nils Große Hokamp; Moritz H Albrecht; Leon D Gruenewald; Ibrahim Yel; Jan Borggrefe; Stefan Wesarg; Katrin Eichler; Iris Burck; Tatjana Gruber-Rouh; Lukas Lenga; Thomas J Vogl; Simon S Martin; Julian L Wichmann; Renate M Hammerstingl; Leona S Alizadeh; Christoph Mader; Nicole A Huizinga; Tommaso D'Angelo; Giorgio Ascenti; Silvio Mazziotti; Christian Booz Journal: Eur Radiol Exp Date: 2021-10-05