Literature DB >> 3188155

In vitro culture of Echinococcus multilocularis: protoscolicidal action of praziquantel and albendazole sulphoxide.

D H Taylor1, D L Morris.   

Abstract

The metacestode stage of Echinococcus multilocularis was cultured in vitro. Sensitivity of protoscoleces to the presence of albendazole sulphoxide, praziquantel and methanol was assessed. 10 micrograms/litre of praziquantel or 500 micrograms/litre of albendazole sulphoxide significantly reduced protoscolex viability. The presence of methanol (at 0.25%) had no significant effect. In vitro culture of E. multilocularis can be used to assess possible chemotherapeutic agents.

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Year:  1988        PMID： 3188155     DOI： 10.1016/0035-9203(88)90443-9

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  6 in total

Review 1.  Anthelminthic agents: some recent developments and their clinical application.

Authors:  G C Cook
Journal:  Postgrad Med J       Date:  1991-01       Impact factor: 2.401

2.  Sensitive in vitro system to assess morphological and biochemical effects of praziquantel and albendazole on Taenia solium cysts.

Authors:  S Mahanty; A Paredes; M Marzal; E Gonzalez; S Rodriguez; P Dorny; C Guerra-Giraldez; H H Garcia; T Nash
Journal:  Antimicrob Agents Chemother       Date:  2010-11-01       Impact factor: 5.191

3.  Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets.

Authors:  Mar Siles-Lucas; Adriano Casulli; Roberto Cirilli; David Carmena
Journal:  PLoS Negl Trop Dis       Date:  2018-04-20

4.  Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model.

Authors:  D H Taylor; D L Morris; D Reffin; K S Richards
Journal:  Gut       Date:  1989-10       Impact factor: 23.059

5.  In vitro effects of albendazole sulfoxide and praziquantel against Taenia solium and Taenia crassiceps cysts.

Authors:  Francisca Palomares; Guadalupe Palencia; Rodolfo Pérez; Dinora González-Esquivel; Nelly Castro; Helgi Jung Cook
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

6.  Development of a movement-based in vitro screening assay for the identification of new anti-cestodal compounds.

Authors:  Dominic Ritler; Reto Rufener; Heinz Sager; Jacques Bouvier; Andrew Hemphill; Britta Lundström-Stadelmann
Journal:  PLoS Negl Trop Dis       Date:  2017-05-17
  6 in total

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