| Literature DB >> 3188078 |
K S Pillai1, A T Mathai, P B Deshmukh.
Abstract
A sublethal concentration (one-tenth of the LD50) of fluoride (F) (5.2 mg F/kg body weight) was administered to Swiss albino mice (male) daily for 35 days. These mice showed a decrease in body weight gain, and food and water consumption. A significant decrease in red blood cell counts and an increase in white blood cell counts were seen in fluoride-administered mice. These animals also showed a decline in albumin, total protein, cholesterol, glucose and alkaline phosphatase activity in the serum. The fluoride content significantly increased in different organs of these animals. Sperm did not show any abnormalities due to fluoride toxicity.Entities:
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Year: 1988 PMID： 3188078 DOI： 10.1016/0378-4274(88)90125-7
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372