Julian Kaufman1, Davor Caric2, Katarina Vukojevic1. 1. Department of Anatomy, Histology and Embryology. School of Medicine, University of Split, Soltanska 2, 21000, Split, Croatia. 2. Department of Orthopedic Surgery and Traumatology, KBC Split - Krizine, Soltanska 1, 21000, Split, Croatia.
Abstract
OBJECTIVES: We investigated the expression of Syndecan-1 and HSP-70 in synovial, chondral and subchondral tissue in the hips of patients with osteoarthritis (OA). METHODS: Total hip arthroplasty was performed on 6 patients and 3 controls. Patients were divided into two groups according to disease severity. The tissues were immunohistochemically analyzed. RESULTS: Cartilage and subchondral tissue in patients with severe OA contained abundant positive cells with a mean positive percentage of 94,51 ± 5% and 78,95 ± 14% for Syndecan-1 and 94,42 ± 5% and 75,67 ± 17% for HSP-70, respectively. CONCLUSION: In conclusion, HSP-70 and Syndecan-1 might play a role in the onset and regulation of OA in the hip.
OBJECTIVES: We investigated the expression of Syndecan-1 and HSP-70 in synovial, chondral and subchondral tissue in the hips of patients with osteoarthritis (OA). METHODS: Total hip arthroplasty was performed on 6 patients and 3 controls. Patients were divided into two groups according to disease severity. The tissues were immunohistochemically analyzed. RESULTS: Cartilage and subchondral tissue in patients with severe OA contained abundant positive cells with a mean positive percentage of 94,51 ± 5% and 78,95 ± 14% for Syndecan-1 and 94,42 ± 5% and 75,67 ± 17% for HSP-70, respectively. CONCLUSION: In conclusion, HSP-70 and Syndecan-1 might play a role in the onset and regulation of OA in the hip.
Authors: Laurent Grossin; Christel Cournil-Henrionnet; Astrid Pinzano; Nadège Gaborit; Dominique Dumas; Stéphanie Etienne; Jean François Stoltz; Bernard Terlain; Patrick Netter; Lluis M Mir; Pierre Gillet Journal: FASEB J Date: 2006-01 Impact factor: 5.191
Authors: K Takahashi; T Kubo; R S Goomer; D Amiel; K Kobayashi; J Imanishi; R Teshima; Y Hirasawa Journal: Osteoarthritis Cartilage Date: 1997-09 Impact factor: 6.576
Authors: Eun Ha Kang; Dong Jo Kim; Eun Young Lee; Yun Jong Lee; Eun Bong Lee; Yeong Wook Song Journal: Arthritis Res Ther Date: 2009-08-27 Impact factor: 5.156