Literature DB >> 31879281

Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting.

Matias A Avila1, Jean-François Dufour2, Alexander L Gerbes3, Fabien Zoulim4, Ramon Bataller5, Patrizia Burra6, Helena Cortez-Pinto7, Bin Gao8, Ian Gilmore9, Philippe Mathurin10, Christophe Moreno11, Vladimir Poznyak12, Bernd Schnabl13, Gyongyi Szabo14, Maja Thiele15, Mark R Thursz16.   

Abstract

Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area.In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention. This paper summarises the discussion and its conclusions. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  alcohol; alcoholic liver disease; cirrhosis; fibrosis; liver transplantation

Mesh:

Year:  2019        PMID: 31879281      PMCID: PMC7236084          DOI: 10.1136/gutjnl-2019-319720

Source DB:  PubMed          Journal:  Gut        ISSN: 0017-5749            Impact factor:   23.059


  146 in total

1.  Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis.

Authors:  Katharina Brandl; Phillipp Hartmann; Lily J Jih; Donald P Pizzo; Josepmaria Argemi; Meritxell Ventura-Cots; Sally Coulter; Christopher Liddle; Lei Ling; Stephen J Rossi; Alex M DePaoli; Rohit Loomba; Wajahat Z Mehal; Derrick E Fouts; Michael R Lucey; Francisco Bosques-Padilla; Philippe Mathurin; Alexander Louvet; Guadalupe Garcia-Tsao; Elizabeth C Verna; Juan G Abraldes; Robert S Brown; Victor Vargas; Jose Altamirano; Juan Caballería; Debbie Shawcross; Peter Stärkel; Samuel B Ho; Ramon Bataller; Bernd Schnabl
Journal:  J Hepatol       Date:  2018-04-12       Impact factor: 25.083

2.  Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease.

Authors:  Anna Janina Engstler; Tobias Aumiller; Christian Degen; Marion Dürr; Eva Weiss; Ina Barbara Maier; Jörn Markus Schattenberg; Cheng Jun Jin; Cathrin Sellmann; Ina Bergheim
Journal:  Gut       Date:  2015-05-25       Impact factor: 23.059

3.  Is Granulocyte Colony Stimulating Factor a New Treatment for Alcoholic Hepatitis?

Authors:  Timothy R Morgan
Journal:  Clin Gastroenterol Hepatol       Date:  2018-06-18       Impact factor: 11.382

4.  Liver transplantation for alcoholic liver disease.

Authors:  Vibha Varma; Kerry Webb; Darius F Mirza
Journal:  World J Gastroenterol       Date:  2010-09-21       Impact factor: 5.742

5.  Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.

Authors:  Richard Moreau; Rajiv Jalan; Pere Gines; Marco Pavesi; Paolo Angeli; Juan Cordoba; Francois Durand; Thierry Gustot; Faouzi Saliba; Marco Domenicali; Alexander Gerbes; Julia Wendon; Carlo Alessandria; Wim Laleman; Stefan Zeuzem; Jonel Trebicka; Mauro Bernardi; Vicente Arroyo
Journal:  Gastroenterology       Date:  2013-03-06       Impact factor: 22.682

6.  Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study.

Authors:  Rohit Loomba; Hwai-I Yang; Jun Su; David Brenner; Elizabeth Barrett-Connor; Uchenna Iloeje; Chien-Jen Chen
Journal:  Am J Epidemiol       Date:  2013-01-24       Impact factor: 4.897

7.  Tributyrin supplementation protects mice from acute ethanol-induced gut injury.

Authors:  Gail A Cresci; Katelyn Bush; Laura E Nagy
Journal:  Alcohol Clin Exp Res       Date:  2014-05-30       Impact factor: 3.455

Review 8.  Diagnosis and Pharmacotherapy of Alcohol Use Disorder: A Review.

Authors:  Henry R Kranzler; Michael Soyka
Journal:  JAMA       Date:  2018-08-28       Impact factor: 56.272

9.  Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data From Controlled Trials.

Authors:  Alexandre Louvet; Mark R Thursz; Dong Joon Kim; Julien Labreuche; Stephen R Atkinson; Sandeep Singh Sidhu; John G O'Grady; Evangelos Akriviadis; Emmanouil Sinakos; Robert L Carithers; Marie-José Ramond; Willis C Maddrey; Timothy R Morgan; Alain Duhamel; Philippe Mathurin
Journal:  Gastroenterology       Date:  2018-05-05       Impact factor: 22.682

10.  Prednisolone or pentoxifylline for alcoholic hepatitis.

Authors:  Mark R Thursz; Paul Richardson; Michael Allison; Andrew Austin; Megan Bowers; Christopher P Day; Nichola Downs; Dermot Gleeson; Alastair MacGilchrist; Allister Grant; Steven Hood; Steven Masson; Anne McCune; Jane Mellor; John O'Grady; David Patch; Ian Ratcliffe; Paul Roderick; Louise Stanton; Nikhil Vergis; Mark Wright; Stephen Ryder; Ewan H Forrest
Journal:  N Engl J Med       Date:  2015-04-23       Impact factor: 91.245

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  22 in total

1.  Identification of a protective Bacteroides strain of alcoholic liver disease and its synergistic effect with pectin.

Authors:  Qiangqiang Wang; Yating Li; Longxian Lv; Huiyong Jiang; Ren Yan; Shuting Wang; Yanmeng Lu; Zhengjie Wu; Jian Shen; Shiman Jiang; Jiawen Lv; Shengjie Li; Aoxiang Zhuge; Lanjuan Li
Journal:  Appl Microbiol Biotechnol       Date:  2022-05-13       Impact factor: 4.813

2.  Multiparametric magnetic resonance imaging/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol-associated liver disease.

Authors:  Jingbiao Chen; Rosa Martin-Mateos; Jiahui Li; Ziying Yin; Jie Chen; Xin Lu; Kevin J Glaser; Taofic Mounajjed; Hiroaki Yashiro; Jenifer Siegelman; Christopher T Winkelmann; Jin Wang; Richard L Ehman; Vijay H Shah; Meng Yin
Journal:  Alcohol Clin Exp Res       Date:  2021-09-05       Impact factor: 3.928

3.  Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis.

Authors:  Ruixue Ren; Yong He; Dong Ding; Aoyuan Cui; Huarui Bao; Jing Ma; Xin Hou; Yu Li; Dechun Feng; Xiaoling Li; Suthat Liangpunsakul; Bin Gao; Hua Wang
Journal:  Hepatology       Date:  2021-12-05       Impact factor: 17.298

4.  Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure.

Authors:  Jing Ma; Adrien Guillot; Zhihong Yang; Bryan Mackowiak; Seonghwan Hwang; Ogyi Park; Brandon J Peiffer; Ali Reza Ahmadi; Luma Melo; Praveen Kusumanchi; Nazmul Huda; Romil Saxena; Yong He; Yukun Guan; Dechun Feng; Pau Sancho-Bru; Mengwei Zang; Andrew MacGregor Cameron; Ramon Bataller; Frank Tacke; Zhaoli Sun; Suthat Liangpunsakul; Bin Gao
Journal:  J Clin Invest       Date:  2022-07-15       Impact factor: 19.456

5.  Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B-Lamin B1 Interaction in Alcoholic Fatty Liver Disease.

Authors:  Xiaoyu Qi; Shuguo Zheng; Mingyue Ma; Naqi Lian; Hongting Wang; Lerong Chen; Anping Song; Chunfeng Lu; Shizhong Zheng; Huanhuan Jin
Journal:  Front Pharmacol       Date:  2022-06-28       Impact factor: 5.988

6.  β-catenin ISGylation promotes lipid deposition and apoptosis in ethanol-stimulated liver injury models.

Authors:  Qi Ding; Guodong Zhang; Yang Wang; Lei Xu; Meifei Wu; Yiwen Zhou; Tao Xu; Xiaoming Meng; Cheng Huang; Lei Zhang
Journal:  Redox Rep       Date:  2022-12       Impact factor: 5.696

Review 7.  Interleukin-22 in alcoholic hepatitis and beyond.

Authors:  Xiaogang Xiang; Seonghwan Hwang; Dechun Feng; Vijay H Shah; Bin Gao
Journal:  Hepatol Int       Date:  2020-09-05       Impact factor: 6.047

Review 8.  Role of non-Genetic Risk Factors in Exacerbating Alcohol-related organ damage.

Authors:  Natalia A Osna; Rakesh Bhatia; Christopher Thompson; Surinder K Batra; Sushil Kumar; Yeonhee Cho; Gyongyi Szabo; Patricia E Molina; Steven A Weinman; Murali Ganesan; Kusum K Kharbanda
Journal:  Alcohol       Date:  2020-06-01       Impact factor: 2.405

9.  Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis.

Authors:  Pradeep K Shukla; Avtar S Meena; Kesha Dalal; Cherie Canelas; Geetha Samak; Joseph F Pierre; RadhaKrishna Rao
Journal:  Sci Rep       Date:  2021-01-12       Impact factor: 4.379

10.  Clinical characteristics of sarcopenia in patients with alcoholic liver cirrhosis.

Authors:  Chisato Saeki; Tomoya Kanai; Masanori Nakano; Tsunekazu Oikawa; Yuichi Torisu; Masayuki Saruta; Akihito Tsubota
Journal:  JGH Open       Date:  2021-05-29
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