Yan Zhao1, Rui Qin2, Xianghua Ma3, Zhenying Qin4, Zi Yang4, Hong Hong5, Heyu Lv6, Kan Ye7, Yarong Wei8, Wen Zheng9, Hongxia Qi10, Yufei Ni11, Li Zhang12, Juhua Yan13, Guoqin Liu14, Aiping Wu15. 1. Department of Clinical Nutrition, Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China. 2. Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China. Electronic address: qinrui329@163.com. 3. Department of Clinical Nutrition, Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China. Electronic address: xianghuama@sina.com.cn. 4. Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China. 5. Department of Child Health Care, Drum Tower Maternity and Child Health Care Institute, Nanjing, 210009, China. 6. Department of Child Health Care, Jiangning Maternity and Child Health Care Institute, Nanjing, 211100, China. 7. Department of Child Health Care, Suzhou Municipal Hospital, Suzhou, 215000, China. 8. Department of Child Health Care, Wuxi Maternity and Child Health Care Hospital, Wuxi, 214000, China. 9. Department of Child Health Care, Yancheng Maternity and Child Health Care Institute, Yancheng, 224000, China. 10. Department of Child Health Care, Xuzhou Children's Hospital, Xuzhou, 221000, China. 11. Department of Child Health Care, Nantong Maternity and Child Health Care Hospital, Nantong, 226000, China. 12. Department of Child Health Care, Huai'an Maternity and Child Health Care Hospital, Huai'an, 223001, China. 13. Department of Child Health Care, Kunshan Maternity and Child Health Care Institute, Kunshan, 215300, China. 14. Department of Child Health Care, Dafeng Maternity and Child Health Care Hospital, Dafeng, 224100, China. 15. Department of Child Health Care, Xinghua Maternity and Child Health Care Hospital, Xinghua, 225700, China.
Abstract
OBJECTIVE: Data on obesity in relation to bone mineral density(BMD) in infants and preschool children were sparse in China. The objective of this study was to examine the associations between body mass index (BMI) and BMD. SUBJECTS AND METHODS: This was a large population-based multicenter study in which the representative children aged 0-5 years were recruited from 13 Children's Health Care Centers by a stratified cluster random-sampling method in Jiangsu Province, China. BMD was measured by using quantitative ultrasound. The association of BMD with BMI and obesity were evaluated using multiple linear regression and logistic regression analysis taking into account the effects of confounders. The relations between age, weight, height, BMI and BMD were analyzed by using Pearson's correlation and further tested using partial correlation in the additive model. RESULTS: A total of 5,289 children (2786 boys and 2503 girls) were recruited. The BMD was positively linear relation with age, length/height, and was inversely linear relation with BMI (r=0.711, P<0.001; r=0.727, P<0.001; r=-0.318, P<0.001, respectively). The BMD gradually increased when the weight was in the range within 21.2kg, but started to gain slowlyand even decreased when the weight was over 21.2kg. After adjusting for confounders, compared with control group, children with obesityhad higher odds of low BMD (OR 95%CI: 2.73 (1.57, 4.76), P<0.001), the speed of sound (SOS)value in children with obesity was lower 47.45 (β=-47.45, 95%CI=-85.07, -9.83, P=0.013). CONCLUSIONS: Adiposity was not advantageous for bone mineral density in 0-5-year-old Chinese children.
OBJECTIVE: Data on obesity in relation to bone mineral density(BMD) in infants and preschool children were sparse in China. The objective of this study was to examine the associations between body mass index (BMI) and BMD. SUBJECTS AND METHODS: This was a large population-based multicenter study in which the representative children aged 0-5 years were recruited from 13 Children's Health Care Centers by a stratified cluster random-sampling method in Jiangsu Province, China. BMD was measured by using quantitative ultrasound. The association of BMD with BMI and obesity were evaluated using multiple linear regression and logistic regression analysis taking into account the effects of confounders. The relations between age, weight, height, BMI and BMD were analyzed by using Pearson's correlation and further tested using partial correlation in the additive model. RESULTS: A total of 5,289 children (2786 boys and 2503 girls) were recruited. The BMD was positively linear relation with age, length/height, and was inversely linear relation with BMI (r=0.711, P<0.001; r=0.727, P<0.001; r=-0.318, P<0.001, respectively). The BMD gradually increased when the weight was in the range within 21.2kg, but started to gain slowlyand even decreased when the weight was over 21.2kg. After adjusting for confounders, compared with control group, children with obesityhad higher odds of low BMD (OR 95%CI: 2.73 (1.57, 4.76), P<0.001), the speed of sound (SOS)value in children with obesity was lower 47.45 (β=-47.45, 95%CI=-85.07, -9.83, P=0.013). CONCLUSIONS: Adiposity was not advantageous for bone mineral density in 0-5-year-old Chinese children.