MicroRNA-613: A novel tumor suppressor in human cancers.

MicroRNAs (miRNAs) are short-chain non-coding RNAs that act as critical roles in malignant tumorigenesis via regulating the expression of tumor-associated genes through post-transcriptional level based on specific binding to their target genes. MicroRNA-613 (miR-613) is a new-found miRNA and emerging evidences show that miR-613 participates in multiple physiological and pathological processes. Recent studies have exhibited that miR-613 is abnormally expressed in a variety of cancers and act as important roles in the progression of cancers. To be specific, miR-613 is generally identified as a tumor suppressor in multiple cancers. In this review, we systematically summarize the roles of miR-613 and highlight the potential correlation between miR-613 expression and clinical features in human cancers.