Kei Yane1, Masaki Kuwatani2, Makoto Yoshida3, Takuma Goto4, Ryusuke Matsumoto5, Hideyuki Ihara6, Toshinori Okuda7, Yoko Taya8, Nobuyuki Ehira9, Taiki Kudo10, Takeya Adachi11, Kazunori Eto12, Manabu Onodera13, Itsuki Sano14, Masanori Nojima15, Akio Katanuma1. 1. Center for Gastroenterology, Teine-Keijinkai Hospital, Hokkaido, Japan. 2. Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Hokkaido, Japan. 3. Department of Medical Oncology, Sapporo Medical University, Hokkaido, Japan. 4. Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Hokkaido, Japan. 5. Department of Gastroenterology, Obihiro Kosei Hospital, Hokkaido, Japan. 6. Department of Gastroenterology, Tonan Hospital, Hokkaido, Japan. 7. Department of Gastroenterology, Oji General Hospital, Hokkaido, Japan. 8. Department of Gastroenterology, National Hospital Organization Hokkaido Medical Center, Hokkaido, Japan. 9. Department of Gastroenterology, Japanese Red Cross Kitami Hospital, Hokkaido, Japan. 10. Department of Gastroenterology, Hakodate Municipal Hospital, Hokkaido, Japan. 11. Department of Gastroenterology, Otaru City General Hospital, Hokkaido, Japan. 12. Department of Gastroenterology, Tomakomai City Hospital, Hokkaido, Japan. 13. Department of Gastroenterology, NTT Medical Center Sapporo, Hokkaido, Japan. 14. Department of Gastroenterology, Kushiro Rosai Hospital, Hokkaido, Japan. 15. Center for Translational Research, Institute of Medical Science Hospital, University of Tokyo, Tokyo, Japan.
Abstract
BACKGROUND AND AIMS: Needle tract seeding after preoperative endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for pancreatic body and tail cancer has been reported. This study aimed to investigate the long-term outcomes, including the needle tract seeding ratio, of patients undergoing distal pancreatectomy for pancreatic body and tail cancer diagnosed preoperatively by EUS-FNA. METHODS: This retrospective, observational cohort study assessed patients from three university hospitals and 11 tertiary referral centers. All patients who underwent distal pancreatectomy for invasive cancer of the pancreatic body and tail between January 2006 and December 2015 were identified and reviewed. Needle tract seeding rate, recurrence-free survival (RFS), and overall survival (OS) were evaluated. RESULTS: Of the 301 total patients analyzed, 176 underwent preoperative EUS-FNA (EUS-FNA group) and 125 did not (non-EUS-FNA group). The median follow-up periods of the EUS-FNA group and non-EUS-FNA group were 32.8 and 30.1 months. Six patients (3.4%) in the EUS-FNA group were diagnosed as having needle tract seeding. The 5-year cumulative needle tract seeding rate estimated using Fine and Gray's method was 3.8% (95% CI 1.6-7.8%). The median RFS or OS was not significantly different between the EUS-FNA group and the non-EUS-FNA group (23.7 vs 16.9 months: P = 0.205; 48.0 vs 43.9 months: P = 0.392). CONCLUSION: Although preoperative EUS-FNA for pancreatic body and tail cancer has no negative effect on RFS or OS, needle tract seeding after EUS-FNA was observed to have a non-negligible rate. (UMIN000030719).
BACKGROUND AND AIMS: Needle tract seeding after preoperative endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for pancreatic body and tail cancer has been reported. This study aimed to investigate the long-term outcomes, including the needle tract seeding ratio, of patients undergoing distal pancreatectomy for pancreatic body and tail cancer diagnosed preoperatively by EUS-FNA. METHODS: This retrospective, observational cohort study assessed patients from three university hospitals and 11 tertiary referral centers. All patients who underwent distal pancreatectomy for invasive cancer of the pancreatic body and tail between January 2006 and December 2015 were identified and reviewed. Needle tract seeding rate, recurrence-free survival (RFS), and overall survival (OS) were evaluated. RESULTS: Of the 301 total patients analyzed, 176 underwent preoperative EUS-FNA (EUS-FNA group) and 125 did not (non-EUS-FNA group). The median follow-up periods of the EUS-FNA group and non-EUS-FNA group were 32.8 and 30.1 months. Six patients (3.4%) in the EUS-FNA group were diagnosed as having needle tract seeding. The 5-year cumulative needle tract seeding rate estimated using Fine and Gray's method was 3.8% (95% CI 1.6-7.8%). The median RFS or OS was not significantly different between the EUS-FNA group and the non-EUS-FNA group (23.7 vs 16.9 months: P = 0.205; 48.0 vs 43.9 months: P = 0.392). CONCLUSION: Although preoperative EUS-FNA for pancreatic body and tail cancer has no negative effect on RFS or OS, needle tract seeding after EUS-FNA was observed to have a non-negligible rate. (UMIN000030719).
Authors: Martin Loveček; Pavel Skalický; Ondřej Urban; Jana Tesaříková; Martin Kliment; Róbert Psár; Hana Švébišová; Kateřina Urban; Beatrice Mohelníková-Duchoňová; Dušan Klos; Martin Stašek Journal: Biomedicines Date: 2022-06-12
Authors: Moon Jae Chung; Se Woo Park; Seong-Hun Kim; Chang Min Cho; Jun-Ho Choi; Eun Kwang Choi; Tae Hoon Lee; Eunae Cho; Jun Kyu Lee; Tae Jun Song; Jae Min Lee; Jun Hyuk Son; Jin Suk Park; Chi Hyuk Oh; Dong-Ah Park; Jeong-Sik Byeon; Soo Teik Lee; Ho Gak Kim; Hoon Jai Chun; Ho Soon Choi; Chan Guk Park; Joo Young Cho Journal: Clin Endosc Date: 2021-03-24
Authors: Moon Jae Chung; Se Woo Park; Seong-Hun Kim; Chang Min Cho; Jun-Ho Choi; Eun Kwang Choi; Tae Hoon Lee; Eunae Cho; Jun Kyu Lee; Tae Jun Song; Jae Min Lee; Jun Hyuk Son; Jin Suk Park; Chi Hyuk Oh; Dong-Ah Park; Jeong-Sik Byeon; Soo Teik Lee; Ho Gak Kim; Hoon Jai Chun; Ho Soon Choi; Chan Guk Park; Joo Young Cho Journal: Gut Liver Date: 2021-05-15 Impact factor: 4.519