| Literature DB >> 3187533 |
E Turner1, L J Hager, B M Shapiro.
Abstract
Despite its potential toxicity, H2O2 is used as an extracellular oxidant by Stronglylocentrotus purpuratus eggs to cross-link their fertilization envelopes. These eggs contain 5 mM 1-methyl-N alpha,N alpha-dimethyl-4-mercaptohistidine (ovothiol C), which reacts with H2O2. In consuming H2O2 and being reduced by glutathione, ovothiol acts as a glutathione peroxidase and replaces the function of the enzyme in eggs. The ovothiol system is more effective than egg catalase in destroying H2O2 at concentrations produced during fertilization and constitutes a principal mechanism for preventing oxidative damage at fertilization.Entities:
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Year: 1988 PMID： 3187533 DOI： 10.1126/science.3187533
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728