Q Sun1, Q Wang1, X Wang1, X Ji2, S Sang3, S Shao4, Y Zhao1, Y Xiang1, Y Xue1, J Li1, G Wang4, M Lv3, F Xue2, C Qiu1,5, Y Du1. 1. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China. 2. Department of Biostatistics, School of Public Health, Shandong University, Jinan, China. 3. Department of Clinical Epidemiology, Qilu Hospital Affiliated to Shandong University, Jinan, China. 4. Department of Radiology, Shandong Medical Imaging Research Institute Affiliated to Shandong University, Jinan, China. 5. Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet Stockholm University, Stockholm, Sweden.
Abstract
BACKGROUND AND PURPOSE: This study was to investigate the prevalence and cardiovascular risk factors (CRFs) of asymptomatic intracranial atherosclerotic stenosis (aICAS) amongst middle-aged and older adults living in rural communities in China. METHODS: This population-based study included 2019 subjects (aged ≥40 years, 52.3% women) who were free of stroke and living in rural communities in China. From October 2017 to May 2018, data on demographics, CRFs and health conditions were collected through face-to-face interviews, physical examination and laboratory tests. Asymptomatic ICAS was detected through a two-phase procedure: a screening phase with transcranial Doppler ultrasound, followed by a diagnostic phase with magnetic resonance angiography examination. Multivariable logistic regression models were used to analyse CRFs associated with aICAS. RESULTS: Of the 2019 participants, aICAS was detected in 153 persons. The overall prevalence of aICAS was 7.6%, and the prevalence of moderate-to-severe aICAS was 5.0%. The multi-adjusted odds ratio (95% confidence interval) of aICAS associated with CRFs was 2.40 (1.56-3.69) for hypertension, 1.91 (1.32-2.76) for high hypersensitive C-reactive protein, 1.68 (1.14-2.49) for diabetes and 1.61 (1.08-2.41) for overweight or obesity. When these four CRFs were aggregated, compared with participants without any of these factors, the multi-adjusted odds ratios (95% confidence interval) of aICAS for persons concurrently having one, two and three or more of these factors were 1.14 (0.52-2.48), 2.91 (1.42-5.99) and 5.51 (2.64-11.50), respectively (P for linear trend <0.001). CONCLUSIONS: Asymptomatic ICAS is common amongst rural-dwelling middle-aged and older Chinese people. Hypertension, diabetes, overweight or obesity and high hypersensitive C-reactive protein, especially when coexisting, are strongly associated with aICAS.
BACKGROUND AND PURPOSE: This study was to investigate the prevalence and cardiovascular risk factors (CRFs) of asymptomatic intracranial atherosclerotic stenosis (aICAS) amongst middle-aged and older adults living in rural communities in China. METHODS: This population-based study included 2019 subjects (aged ≥40 years, 52.3% women) who were free of stroke and living in rural communities in China. From October 2017 to May 2018, data on demographics, CRFs and health conditions were collected through face-to-face interviews, physical examination and laboratory tests. Asymptomatic ICAS was detected through a two-phase procedure: a screening phase with transcranial Doppler ultrasound, followed by a diagnostic phase with magnetic resonance angiography examination. Multivariable logistic regression models were used to analyse CRFs associated with aICAS. RESULTS: Of the 2019 participants, aICAS was detected in 153 persons. The overall prevalence of aICAS was 7.6%, and the prevalence of moderate-to-severe aICAS was 5.0%. The multi-adjusted odds ratio (95% confidence interval) of aICAS associated with CRFs was 2.40 (1.56-3.69) for hypertension, 1.91 (1.32-2.76) for high hypersensitiveC-reactive protein, 1.68 (1.14-2.49) for diabetes and 1.61 (1.08-2.41) for overweight or obesity. When these four CRFs were aggregated, compared with participants without any of these factors, the multi-adjusted odds ratios (95% confidence interval) of aICAS for persons concurrently having one, two and three or more of these factors were 1.14 (0.52-2.48), 2.91 (1.42-5.99) and 5.51 (2.64-11.50), respectively (P for linear trend <0.001). CONCLUSIONS: Asymptomatic ICAS is common amongst rural-dwelling middle-aged and older Chinese people. Hypertension, diabetes, overweight or obesity and high hypersensitiveC-reactive protein, especially when coexisting, are strongly associated with aICAS.
Authors: Qiao Wang; Yuanyuan Zhao; Xiang Wang; Xiaokang Ji; Shaowei Sang; Sai Shao; Xiaotong Ma; Guangbin Wang; Ming Lv; Fuzhong Xue; Yifeng Du; Qinjian Sun Journal: BMJ Open Diabetes Res Care Date: 2020-12
Authors: Xiaotong Ma; Shaowei Sang; Yuanyuan Zhao; Xiang Wang; Xiaokang Ji; Sai Shao; Guangbin Wang; Fuzhong Xue; Yifeng Du; Ming Lv; Qinjian Sun Journal: Front Cardiovasc Med Date: 2022-03-02